Results 81 to 90 of about 2,363,671 (275)

Sailing the Deep Blue Sea of Decaying Burgers Turbulence

, 1999
We study Lagrangian trajectories and scalar transport statistics in decaying Burgers turbulence. We choose velocity fields, solutions of the inviscid Burgers equation, whose probability distributions are specified by Kida's statistics.
Bauer, Michel, Bernard, Denis
core   +3 more sources

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Long-Term Probabilistic Forecast of Vegetation Conditions Using Climate Attributes in the Four Corners Region

Remote Sensing
Weather conditions can drastically alter the state of crops and rangelands and, in turn, impact the incomes and food security of individuals worldwide. Satellite-based remote sensing offers an effective way to monitor vegetation and climate variables on ...
Erika McPhillips, Hyeongseong Lee, Xiangyu Xie, Kathy Baylis, Chris Funk, Mengyang Gu   +5 more
doaj   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Forecast Encompassing Tests and Probability Forecasts [PDF]

We consider tests of forecast encompassing for probability forecasts, for both quadratic and logarithmic scoring rules. We propose test statistics for the null of forecast encompassing, present the limiting distributions of the test statistics, and ...
Clements, Michael P, Harvey, David I
core  

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

gnSPADE: Incorporating Gene Network Structures Enhances Reference‐Free Deconvolution in Spatial Transcriptomics

Advanced Intelligent Systems
Spatial transcriptomics (ST) technologies offer unprecedented insights into the spatial organization of gene expression, allowing for the study of tissue architecture, domain boundaries, and cell–cell interactions.
Aoqi Xie, Yuehua Cui
doaj   +1 more source

Variable Selection for Generalized Single-Index Varying-Coefficient Models with Applications to Synergistic G × E Interactions

Mathematics
Complex diseases such as type 2 diabetes are influenced by both environmental and genetic risk factors, leading to a growing interest in identifying gene–environment (G × E) interactions.
Shunjie Guan, Xu Liu, Yuehua Cui
doaj   +1 more source

Prognostic Impact of European LeukemiaNet Genetic Risk Stratification System in Adult Patients With Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
This study aimed to evaluate the prognostic value of ELN2017 in predicting survival outcomes and to assess the impact of clinical and molecular factors such as age, FLT3 and NPM1 mutations, and allogeneic hematopoietic stem cell transplantation (allo‐HSCT).
Mobina Shrestha, Bishwas Mandal, Vishal Mandal, Asis Shrestha, Amir Babu Shrestha   +4 more
wiley   +1 more source