Results 81 to 90 of about 631,153 (290)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Defining a braking probability to estimate extreme braking forces on road bridges [PDF]

open access: yes, 2015
A probabilistic approach is necessary to estimate the magnitude of the braking force that compares in terms of return period with the vertical traffic loads present in bridge design codes. A data set from a Danish Field Operational Test served as support
Dumont, André-Gilles   +4 more
core  

On K-means algorithm with the use of Mahalanobis distances [PDF]

open access: yes, 2014
The K-means algorithm is commonly used with the Euclidean metric. While the use of Mahalanobis distances seems to be a straightforward extension of the algorithm, the initial estimation of covariance matrices can be complicated.
Melnykov, Igor   +2 more
core   +2 more sources

The skills required for transition to university and study in biological sciences: A student perspective

open access: yesFEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Influence of culture on secondary school students' understanding of statistics: A Fijian perspective [PDF]

open access: yes, 2014
Although we use statistical notions daily in making decisions, research in statistics education has focused mostly on formal statistics. Further, everyday culture may influence informal ideas of statistics.
Sharma, Sashi
core  

Stein's method in high dimensions with applications [PDF]

open access: yes, 2013
10.1214/11-AIHP473Annales de l'institut Henri Poincare (B) Probability and Statistics492529 ...
Röllin, A., Röllin, Adrian
core   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

open access: yesFEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani   +6 more
wiley   +1 more source

Some theoretical results on neural spike train probability models [PDF]

open access: yes, 2007
10.1214/009053607000000280Annals of Statistics3562691 ...
Chan, H.P., Loh, W.-L.
core   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

open access: yesFEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young   +7 more
wiley   +1 more source

Plithogenic Probability & Statistics are generalizations of MultiVariate Probability & Statistics

open access: yesNeutrosophic Sets and Systems, 2021
In this paper we exemplify the types of Plithogenic Probability and respectively Plithogenic Statistics. Several applications are given. The Plithogenic Probability of an event to occur is composed from the chances that the event occurs with respect to all random variables (parameters) that determine it.
openaire   +1 more source

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