Results 91 to 100 of about 53,712,339 (311)
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
National Vital Statistics System Division of Vital Statistics Newsletter ; March 2021
Inside this issue \u2013 Information on the Vital Records and Health Statistics Accreditation Program; Vital Statistics Modernization Community of Practice updates; and more\u2026nvss-newsletter-march-2021-508 ...
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The topic-prominence parameter [PDF]
, 2013 This article aims to recast the properties of topic-prominent languages and their differences from subject-prominent languages as documented in the functionalist literature into the framework of the Principle-and-Parameter approach.
Xu, Liejiong
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Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Active-Learning Class Activities and Shiny Applications for Teaching Support Vector Classifiers
Journal of Statistics and Data Science EducationSupport vector classifiers are one of the most popular linear classification techniques for binary classification. Different from some commonly seen model fitting criteria in statistics, such as the ordinary least squares criterion and the maximum ...
Qing Wang, Xizhen Cai
doaj +1 more source
National Vital Statistics System Division of Vital Statistics newsletter ; July 2023
Inside this issue \u2013 Updated information regarding the 2022 data year close-outs for death and fetal death files; Notable publication information on homicides among infants in the United States; Vital Statistics Modernization Community of Practice ...
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Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
National Vital Statistics System Division of Vital Statistics newslettter ; January 2023
Inside this issue \u2013 Information regarding a recent change by the Division of Vital Statistics related to HIV and other ICD-10 Chapter 1 infections; Notable publication information on changes in Fetal Mortality in the United States: 2019-2020; Vital ...
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Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
National Vital Statistics System Division of Vital Statistics newsletter ; January 2023
Inside this issue \u2013 Information regarding a recent change by the Division of Vital Statistics related to HIV and other ICD-10 Chapter 1 infections; Notable publication information on changes in Fetal Mortality in the United States: 2019-2020; Vital ...
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