Results 101 to 110 of about 1,700,598 (262)

Do household definitions matter in survey design? [PDF]

Household definitions used in multi-topic household surveys vary between surveys but have potentially significant implications for household composition, production, and poverty statistics.
Beaman, Lori, Dillon, Andrew
core  

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

The Viability of Topic Modeling to Identify Participant Motivations for Enrolling in Online Professional Development

Online Learning
Identifying motivation for enrollment in MOOCs has been an important way to predict participant success rates. But themes for motivation have largely centered around themes for enrolling in any MOOC, and not ones specific to the course being studied.  In
Heather Allmond Barker, Hollylynne S Lee, Shaun Kellogg, Robin Anderson   +3 more
doaj   +1 more source

Implementing an Executive-Function Syllabus: Operational Issues [PDF]

Journal of Systemics, Cybernetics and Informatics, 2016
A recent approach to pedagogic challenge, contrastive to the hierarchy approach of Bloom, Anderson, Gagne, Van Hiele, Marzano, Webb and many others, identifies pedagogic challenge with executive function: Pedagogy is defined as challenging if it ...
Russell Jay Hendel
doaj  

Quality of China's Official Statistics: A Brief Review of Academic Perspectives

The Copenhagen Journal of Asian Studies, 2017
Following the rise of the Chinese economy, interest in the official statistics coming from China is intensifying. Official data on GDP, industrial production and other economic indicators attracts a lot of attention all over the world.
Dmitriy Plekhanov
doaj   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Mapping the Field of Statistics Education Research in Search of Scholarship

International Journal for the Scholarship of Teaching and Learning, 2011
This paper is intended as a contribution to the advancement of scholarship in the field of statistics education, which directly links with the scholarship of teaching and learning.
Linda van der Merwe, Annette Wilkinson
doaj   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Active-Learning Class Activities and Shiny Applications for Teaching Support Vector Classifiers

Journal of Statistics and Data Science Education
Support vector classifiers are one of the most popular linear classification techniques for binary classification. Different from some commonly seen model fitting criteria in statistics, such as the ordinary least squares criterion and the maximum ...
Qing Wang, Xizhen Cai
doaj   +1 more source