Results 161 to 170 of about 2,998,558 (396)
Tumor‐informed whole‐genome sequencing (MRD‐EDGESNV) was applied to detect circulating tumor DNA (ctDNA) in patients with colorectal adenomas. Using a 95% specificity threshold, established from stage III colorectal cancer patients, ctDNA was detected in 50% of symptomatic and 25% of asymptomatic adenoma cases with median tumor fractions of 5.9 × 10−5 ...
Amanda Frydendahl+13 more
wiley +1 more source
Prostate cancer is a leading malignancy with significant clinical heterogeneity in men. An 11‐gene signature derived from dysregulated epithelial cell markers effectively predicted biochemical recurrence‐free survival in patients who underwent radical surgery or radiotherapy.
Zhuofan Mou, Lorna W. Harries
wiley +1 more source
Is Data Cleaning and the Testing of Assumptions still relevant in the 21st Century?
Jason W Osborne
doaj +1 more source
End to dream? British retired residents in Spain and their return patterns [PDF]
Academic production on residential tourism and retirement migration historically focus on movements of arrival in receiving countries. This assumes both the uni-directionality of migrations and the importance of analysing immigrations from the host ...
Jordi Giner-Monfort
doaj
The complex mode of action of the topoisomerase II inhibitor etoposide in triggering apoptosis involves several mechanisms: overexpression of the mitochondrial protein VDAC1, leading to its oligomerization and formation of a large channel that mediates the release of pro‐apoptotic protein; and overexpression of the apoptosis regulators p53, Bax, and ...
Aditya Karunanithi Nivedita+1 more
wiley +1 more source
NAD+ regeneration by mitochondrial complex I NADH dehydrogenase is important for cancer cell proliferation. Specifically, NAD+ is necessary for the activities of NAD+‐dependent deacetylases SIRT3 and SIRT7, which suppress the expression of p21Cip1 cyclin‐dependent kinase inhibitor, an antiproliferative molecule, at the translational and transcriptional
Masato Higurashi+5 more
wiley +1 more source
Better understanding of ‘don’t confuse absence of evidence with evidence of absence’
Rafael Leite Pacheco+3 more
doaj +1 more source
Reliability of Topic Modeling [PDF]
Topic models allow researchers to extract latent factors from text data and use those variables in downstream statistical analyses. However, these methodologies can vary significantly due to initialization differences, randomness in sampling procedures, or noisy data.
arxiv