Results 71 to 80 of about 1,688,539 (296)
Creating and using real-world evidence to answer questions about clinical effectiveness
Journal of Innovation in Health Informatics, 2015 New forms of evidence are needed to complement evidence generated from randomised controlled trials (RCTs). Real-World Evidence (RWE) is a potential new form of evidence, but remains undefined.This paper sets to fill that gap by defining RWE as the ...
Simon de Lusignan +2 more
doaj +1 more source
Sparse Allreduce: Efficient Scalable Communication for Power-Law Data [PDF]
, 2013 Many large datasets exhibit power-law statistics: The web graph, social networks, text data, click through data etc. Their adjacency graphs are termed natural graphs, and are known to be difficult to partition.
Canny, John, Zhao, Huasha
core
An intracellular transporter mitigates the CO2‐induced decline in iron content in Arabidopsis shoots
FEBS Letters, EarlyView.This study identifies a gene encoding a transmembrane protein, MIC, which contributes to the reduction of shoot Fe content observed in plants under elevated CO2. MIC is a putative Fe transporter localized to the Golgi and endosomal compartments. Its post‐translational regulation in roots may represent a potential target for improving plant nutrition ...
Timothy Mozzanino +7 more
wiley +1 more source
Medical graduate views on statistical learning needs for clinical practice: a comprehensive survey
BMC Medical Education, 2019 Background This paper seeks to contribute to a reputable evidence base for required competencies across different topics in statistics and probability (statistical topics) in preparing medical graduates for clinical practice.
Margaret MacDougall +2 more
doaj +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
A Context-Driven Topic Coherence Evaluation Approach Using LLM-Based Embeddings
IEEE AccessTopic modeling has emerged as a vital tool for extracting interpretable topics from large volumes of textual data. Although topic modeling techniques have evolved from the word frequency-based methods to word embedding-based methods, as exemplified by ...
Chibok Yang, Yang Sok Kim
doaj +1 more source
Project Newsletter Iowa Public Health Tracking, July 2013 [PDF]
, 2013 The IDPH Public Health Tracking Program is an excellent way to collect data related to various indicators for Iowans, but those looking for national statistics or data from other states may want to check out the Health Indicators Warehouse ...
core
, 2018 'Style transfer' among images has recently emerged as a very active research topic, fuelled by the power of convolution neural networks (CNNs), and has become fast a very popular technology in social media.
Duong, Ngoc +3 more
core +1 more source
FEBS Letters, EarlyView.At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom +3 more
wiley +1 more source