Results 291 to 300 of about 1,824,100 (361)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Fault analysis and performance improvement of grid-connected doubly fed induction generator through an enhanced crowbar protection scheme. [PDF]

PLoS One
Talani RA, Kaloi GS, Ali A, Abbas G, Emara A, Touti E.   +5 more
europepmc   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

A Novel Rolling Driving Principle-Enabled Linear Actuator for Bidirectional Smooth Motion. [PDF]

Cyborg Bionic Syst
Long D, Wang F, Hu C, Shi C.
europepmc   +1 more source

TREX1, a predator for treating MSI‐H tumors?

Molecular Oncology, EarlyView.
Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya, Joséphine Deneft, Marc Van den Eynde   +2 more
wiley   +1 more source

Insertion of Fluorescent Proteins Near the Plug Domain of MotB Generates Functional Stator Complexes. [PDF]

Microbiologyopen
Gurung JP, Ridone P, Biquet-Bisquert A, Bryant G, Pedaci F, Nord AL, Baker MAB.   +6 more
europepmc   +1 more source

Fault Diagnosis of Static Eccentricity in Marine Diesel Generators Using 2D Short-Time Fourier Transform of Three-Phase Currents. [PDF]

Sensors (Basel)
Joe BJ, Lee JS, Yeo SJ, Cho YJ, Jeon JY.
europepmc   +1 more source

A dual doubly-fed generator system supplied by a five-phase voltage inverter. [PDF]

Sci Rep
Blecharz K, Kondratenko D.
europepmc   +1 more source

Evolution and structural diversity of the MotAB stator: insights into the origins of bacterial flagellar motility. [PDF]

mBio
Puente-Lelievre C, Ridone P, Douglas J, Amritkar K, Kaçar B, Baker MAB, Matzke NJ.   +6 more
europepmc   +1 more source

Broken Rotor Bar Fault Detection for Inverter-Fed Induction Motor with Negative-Sequence Current Analysis. [PDF]

Sensors (Basel)
Ruzimov S, Zhang J, Huang X, Aziz MS.
europepmc   +1 more source