Results 121 to 130 of about 42,768 (298)

Sodium‐glucose cotransporter 2 inhibitors and the risk of late onset epilepsy: A real‐world cohort study

Epilepsia, EarlyView.
Abstract Objective Late onset epilepsy (LOE) is associated with substantial morbidity. Sodium‐glucose cotransporter 2 inhibitors (SGLT2i) may exert neuroprotective effects. This study evaluated the association between SGLT2i and risk of LOE among older adults with type 2 diabetes mellitus.
Bing‐Hua Lin, Hui‐Min Huang, Hui‐An Lin, Sheng‐Feng Lin   +3 more
wiley   +1 more source

Biofluid‐specific variations in circulating 5′ transfer RNA fragments during ictal and interictal states in experimental temporal lobe epilepsy

Epilepsia, EarlyView.
Abstract Objective Circulating small noncoding RNAs represent potential biomarkers of temporal lobe epilepsy (TLE). Recently, two transfer RNA fragments (tRFs), 5′tRF Glu‐CTC and Gly‐GCC, were found to be elevated in plasma samples collected in advance of a seizure in TLE patients, suggesting they may serve as potential wet biomarkers of seizure risk ...
Marie Soukupova, Elena Perez Morrissey, Annunziata Guarino, Pietro Marino, Cristiana Pareo, Nicolò Birtolo, Saad Zaheer, Rachel Stewart, Ina Woods, Felix Rosenow, Hajo Hamer, Péter Körtvélyessy, Shona Pfeiffer, David C. Henshall, Jochen H. M. Prehn, Michele Simonato   +15 more
wiley   +1 more source

Timing of benzodiazepine treatment and mortality in adult patients with generalized convulsive status epilepticus

Medicine in Drug Discovery
Status epilepticus is an emergency condition with a high mortality rate. However, there is currently limited data on the timing of antiepileptic drugs (AED) and mortality, particularly generalized convulsive status epilepticus.
Au Auvichayapat, Verajit Chotmongkol, Kittisak Sawanyawisuth, Somsak Tiamkao   +3 more
doaj   +1 more source

Status epilepticus in children

, 2022
Epileptički status je hitno kliničko stanje u pedijatriji koje se može javiti kod djece bilo koje dobi. Javlja se u omjeru 16-61/100,000 djece, a pojavnost dominantno ovisi o dobi, spolu, socioekonomskim čimbenicima, te osobnim faktorima kao što su ...
Otmačić, Ida
core  

Increased interval between seizure clusters across time in pediatric patients treated with the immediate‐use seizure medication diazepam nasal spray

Epilepsia, EarlyView.
Abstract Objective Seizure clusters, intermittent increases in seizure activity that differ from a patient's usual seizure pattern, may occur despite treatment with a daily anti‐seizure medication. Benzodiazepine‐containing immediate‐use seizure medications (ISMs; also called rescue therapies) are the cornerstone of treatment for seizure clusters ...
James W. Wheless, Eric Segal, Jurriaan M. Peters, Steven M. Wolf, Genei Bougher, Charles Davis, Leock Y. Ngo, Enrique Carrazana, Adrian L. Rabinowicz   +8 more
wiley   +1 more source

Convulsive and non-convulsive status epilepticus

, 2016
This chapter describes the definition, epidemiology, classification, diagnosis, and treatment of status epilepticus, concentrating on the roles that electroencephalography (EEG) plays.
Matthew C. Walker
core   +1 more source

Management of ring chromosome 20 syndrome: Narrative review and consensus recommendations

Epilepsia, EarlyView.
Abstract Ring chromosome 20 (ring 20) is a rare genetic condition usually presenting as developmental and epileptic encephalopathy. The disease is caused by fusion of the long and short arms of chromosome 20. Patients are symptomatic even if there is no loss of genetic material.
Asma Khamis, Emilia Ricci, Maria Paola Canevini, Lieven Lagae, Kentaro Tokumoto, Yushi Inoue, Tim Buckinx, Allison Watson, Kenneth A. Myers   +8 more
wiley   +1 more source

Clinical patterns and outcomes of status epilepticus in patients with tuberous sclerosis complex

, 2017
Hatem S Shehata,1 Hadeer Mahmoud AbdelGhaffar,2 Mohammed Nasreldin,3 Alaa Elmazny,1 Ahmed Abdelalim,1 Asmaa Sabbah,1 Nevin M Shalaby1 1Department of Neurology, Cairo University, Giza, 2Department of Paediatrics, Fayoum University, Fayoum, 3Department of
AbdelGhaffar HM, Abdelalim A, Elmazny A, Nasreldin M, Shehata HS, Shalaby NM, Sabbah A   +6 more
core  

Management of Status Epilepticus

, 2002
Status epilepticus is due to a range of insults to the central nervous system and results in significant mortality rates, especially in the elderly. We review the current management of this disorder in light of the latest developments from recent trials ...
ACF Hui, HC Wong, CY Man
core   +1 more source

Effects of fenfluramine and sigma‐1‐dependent pharmacological and genetic modulation in a mouse kindling model

Epilepsia, EarlyView.
Abstract Objective Sigma‐1 is a chaperone protein that serves as a key homeostatic regulator, implicated in neuronal excitability and seizure control. Positive allosteric modulators offer a use‐dependent means to enhance Sigma‐1 activity, potentially with favorable tolerability compared to direct agonists.
Eva‐Lotta von Rüden, Verena Buchecker, Amelie Wagner, Victoria M. Stocker, Liga Zvejniece, Heidrun Potschka   +5 more
wiley   +1 more source