Results 51 to 60 of about 321,647 (305)
On the way of creation of the CGC of the SSSR: Projects of organization of special bodies for establishment and investigation of atrocities committed by hitlerites in the occupied territories of the SSSR in 1941 [PDF]
The paper analyzes the projects submitted to the Soviet leadership in 1941 for the establishment of organizations for reporting and investigation of war crimes committed by Hitler’s accomplices in the occupied territories of the Soviet Union. Based
Lakizyuk, Andrey Александрович
doaj +1 more source
The Aftermath of Merck: D&O Insecurity in the Security Fraud Arena [PDF]
This Comment will trace the history of Merck, culminating in the Supreme Court’s extension of the statute of limitations periods for private security fraud suits, and discuss the impact this holding will have on future security fraud litigation, both for
Russo, Alexandra
core +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
Attempts at Justice during the Regime Change in Hungary
In the years after Hungary’s regime change, a lively political and public debate emerged about the possibility of justice for the crimes committed during the decades of communist dictatorship.
Áron Máthé
doaj +1 more source
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Statute of Limitations Related to Interests on Late Payment and to Contractual Penalty [PDF]
The paper deals with the impact of passage of time on secondary rights arising from breach of contractual obligation to perform his or her duty duly and in time – on interests on late payment (the claim arising ex lege) and on contractual penalty (as a ...
Daniela Hlobíková
doaj
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source

