Results 91 to 100 of about 37,370,447 (302)
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Steady State Tokamak Sustained by Bootstrap Current Without Seed Current [PDF]
, 1992 Steady state tokamak solution is studied by taking into account the current diffusivity. The seed current for generating the Bootstrap current is supplied through the radial diffusion of the Bootstrap current.
Itoh, S.-I., Itoh, K., Fukuyama, A.
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Kinetic Modeling of Time-Dependent Enzyme Inhibition by Pre-Steady-State Analysis of Progress Curves: The Case Study of the Anti-Alzheimer's Drug Galantamine. [PDF]
Int J Mol Sci, 2022 Lamba D, Pesaresi A.
europepmc +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Optimal Design of an Ecofriendly Pickup Truck Overhang and Roof to Reduce the Drag Coefficient
Applied SciencesUntil now, various studies have been conducted on the drag coefficient of pickup trucks, but little research has been conducted on the effect of the front overhang length and roof design on the drag coefficient.
Min Seok Kim +3 more
doaj +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Analysis and Optimization of Reducing Steady State Time for Heating Systems [PDF]
International Journal of Advanced Design and Manufacturing Technology, 2009 Present paper is a result of consideration in reducing steady-state time of heating systems. For this purpose one should study boundary condition of the system until steady state condition.
Farhad Talebi +2 more
doaj
IEEE Access, 2019 Due to many advantages, such as cost-effective production, design freedom, and weight reduction, plastics have replaced metals and ceramics in many fields. However, engineering plastics are good thermal insulators.
Mahdi Soltani +4 more
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Fundamentals of equilibrium and steady-state thermodynamics /
, 2000 This book summarizes the salient features of both equilibrium and steady-state thermodynamic theory under a uniform postulatory viewpoint. The emphasis is upon the formal aspects and logical structure of thermodynamic theory, allowing it to emerge as a ...
Tschoegl, Nicholas W.
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