Results 131 to 140 of about 698,757 (298)

Innovative Application of the Ritz Method to Oil-Gas Seepage Problems: A Novel Variational Approach for Solving Underground Flow Equations

Energies
State-of-the-art commercial simulators (e.g., Eclipse, CMG) predominantly employ finite difference schemes, which face persistent challenges in modeling strongly nonlinear seepage dynamics. This study explores the application of the Ritz method, grounded
Xiongzhi Liu, Hao Yang, Lifei Dong, Ming Lei, Jie Han, Hao Kang   +5 more
doaj   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Non-adiabatic linear response in open quantum systems

SciPost Physics
Adiabatic theorem and non-adiabatic corrections have been widely applied in modern quantum technology. Recently, non-adiabatic linear response theory has been developed to probe the many-body correlations in closed systems.
Xiaotian Nie, Wei Zheng
doaj   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Dynamic Power Flow Modeling Primary and Secondary Frequency Regulations

IEEE Access
In power systems, the steady-state operations following any disturbance can be assessed by means of time-domain simulations, which consider the dynamic of the system without simplifying hypotheses.
Roberto Benato, Giovanni Gardan, Francesco Sanniti   +2 more
doaj   +1 more source

Peroxy radicals from photostationary state deviations and steady state calculations during the Tropospheric OH Photochemistry Experiment at Idaho Hill, Colorado, 1993 [PDF]

, 1997
C. A. Cantrell, R. E. Shetter, Jack G. Calvert, F. L. Eisele, E. J. Williams, Karsten Baumann, W. H. Brune, P. S. Stevens, J. H. Mather   +8 more
openalex   +1 more source

Small Noise Asymptotics for a Stochastic Growth Model [PDF]

We develop analytic asymptotic methods to characterize time series properties of nonlinear dynamic stochastic models. We focus on a stochastic growth model which is representative of the models underlying much of modern macroeconomics.
Noah Williams
core  

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Corrigendum to "Oxidation photochemistry in the Southern Atlantic boundary layer: unexpected deviations of photochemical steady state" published in Atmos. Chem. Phys., 11, 8497–8513, 2011 [PDF]

, 2011
Z. Hosaynali Beygi, Hubertus Fischer, Hartwig Harder, Mònica Martínez, Rolf Sander, Jonathan Williams, D. M. Brookes, P. S. Monks, Jos Lelieveld   +8 more
openalex   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source