Results 151 to 160 of about 17,957,190 (298)
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
EnergiesState-of-the-art commercial simulators (e.g., Eclipse, CMG) predominantly employ finite difference schemes, which face persistent challenges in modeling strongly nonlinear seepage dynamics. This study explores the application of the Ritz method, grounded
Xiongzhi Liu +5 more
doaj +1 more source
Targeted Fast Frequency Response by Decomposing Frequency into Transient and Steady-State Deviations
2023 IEEE International Conference on Energy Technologies for Future Grids (ETFG), 2023 Sánchez Cortés, J. +2 more
openaire +2 more sources
Steady-state security in distribution networks with large wind farms
, 2014 © 2014, The Author(s). Aging network assets, forced and unforced outages, and the way the networks are operated in a deregulated market are of significant concerns to integrate large wind farms in a distribution network.
Syed Islam (23305102) +1 more
core
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Non-adiabatic linear response in open quantum systems
SciPost PhysicsAdiabatic theorem and non-adiabatic corrections have been widely applied in modern quantum technology. Recently, non-adiabatic linear response theory has been developed to probe the many-body correlations in closed systems.
Xiaotian Nie, Wei Zheng
doaj +1 more source
Steady-state solution of a fully coupled system in the limit of large D.
, 2016 As in Fig 2, the near steady-state solution of a fully coupled system was obtained by VCell hybrid for the fast-diffusion limit and validated against Gibson-Bruck stochastic nonspatial solver. Results from each solver are based on 20,000 realizations and
Fei Gao (29262) +4 more
core +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source