Results 61 to 70 of about 1,771,897 (325)

Compatibility of internal transport barrier with steady-state operation in the high bootstrap fraction regime on DIII-D

Nuclear Fusion, 2015
Recent EAST/DIII-D joint experiments on the high poloidal beta tokamak regime in DIII-D have demonstrated fully noninductive operation with an internal transport barrier (ITB) at large minor radius, at normalized fusion performance increased by  ⩾30 ...
A. Garofalo, X. Gong, B. Grierson, Q. Ren, W. Solomon, E. Strait, M. Zeeland, C. Holcomb, O. Meneghini, Sterling P. Smith, G. Staebler, B. Wan, R. Bravenec, R. Budny, S. Ding, J. Hanson, W. Heidbrink, L. Lao, Guoqiang Li, C. Pan, C. Petty, J. Qian, C. Paz-Soldan, Gang Xu   +23 more
semanticscholar   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Steady-State Power Flow Analysis of Cold-Thermal-Electric Integrated Energy System Based on Unified Power Flow Model

Energies, 2019
The integrated energy system includes various energy forms, complex operation modes and tight coupling links, which bring challenges to its steady-state modeling and steady-state power flow calculation.
Lu Qu, Bin Ouyang, Zhichang Yuan, Rong Zeng   +3 more
doaj   +1 more source

Implications of Steady-State Operation on Divertor Design [PDF]

Fusion Technology, 1996
As fusion experiments progress towards long pulse or steady state operation, plasma facing components are undergoing a significant change in their design. This change represents the transition from inertially cooled pulsed systems to steady state designs of significant power handling capacity.
D.L. Sevier, E.E. Reis, C.B. Baxi, G.W. Silke, D.N. Hill, C.P.C. Wong   +5 more
openaire   +1 more source

Integrated operation of steady-state long-pulse H-mode in Experimental Advanced Superconducting Tokamak

Nuclear Fusion, 2019
Recent Experimental Advanced Superconducting Tokamak (EAST) experiments have successfully demonstrated a long-pulse steady-state scenario with improved plasma performance through integrated operation since the last IAEA FEC in 2016.
X. Gong, A. Garofalo, J. Huang, Jinping Qian, C. Holcomb, A. Ekedah, R. Maingi, E. Li, L. Zeng, B. Zhang, Jun Chen, M. Wu, H. Du, Miaohui Li, X. Zhu, Youwen Sun, G. Xu, Q. Zang, L. Wang, Lizhen Zhang, Haiqing Liu, B. Lyu, P. Sun, Siye Ding, X. Zhang, Fukun Liu, Yan-ping Zhao, B. Xiao, Jin-Yong Hu, Chundong Hu, Litian Hu, Jiuyuan Li, B. Wan   +32 more
semanticscholar   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Bimetal sensor averages temperature of nonuniform profile [PDF]

, 1968
Instrument that measures an average temperature across a nonuniform temperature profile under steady-state conditions has been developed. The principle of operation is an application of the expansion of a solid material caused by a change in ...
Dittrich, R. T.
core   +1 more source

Analysis of a Half-Controlled Single-Phase Bridge Circuit with Free-Wheeling Diode (1) [PDF]

, 1966
The operation, mainly in a steady state, of a half controlled single-phase bridge circuit with a finite inductive load, has been treated analytically.
Fukumori, Kooichi, Himei, Toyoji, Inoue, Jyunichi   +2 more
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source