Results 71 to 80 of about 85,684 (266)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Concurrent operation of 10 gyrotrons at W7-X experience and improvement opportunities

EPJ Web of Conferences, 2018
At the stellarator Wendelstein 7-X (W7-X) Electron Cyclotron Resonance Heating (ECRH) is the main heating system for steady-state operation and was the only available heating system during the operation phase OP1.2a in 2017.
Braune H., Brunner K.J., Laqua H.P., Marsen S., Moseev D., Noke F., Purps F., Schneider N., Schulz T., Stange T., Uhren P., Wilde F.   +11 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Feed and Bleed Operating Mode for Electrochemical Flow Cells: Challenges, Solutions and Practical Insights

ChemElectroChem
Electrochemical processes offer promising routes to defossilize the chemical industry by integrating low‐carbon electricity. However, bridging the gap between lab‐scale experimental studies and pilot‐scale industrial applications is still challenging ...
Jonas Baessler, Malte Wehner, Mojtaba Mohseni, Julian Neumann, Matthias Wessling, Robert Keller   +5 more
doaj   +1 more source

Model, Characterization, and Analysis of Steady-State Security Region in AC/DC Power System with a Large Amount of Renewable Energy

Energies, 2017
A conventional steady-state power flow security check only implements point-by-point assessment, which cannot provide a security margin for system operation.
Zhong Chen, Hui Chen, Minhui Zhuang, Siqi Bu   +3 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Operation control and mode adaptive switching strategy for low-voltage flexible DC interconnection systems

电力工程技术
Low-voltage flexible direct currect (LV-FDC) technology represents a vital technical approach to addressing the issues of heavy overloading and power supply reliability in end-user distribution networks.
Changjun JIANG, Haitao LIU, Xiong XIONG, Changhao GUO   +3 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Fuel reid vapor pressure level and ethanol content on stochastic preignition, effects at steady and unsteady engine operation

Applications in Energy and Combustion Science
The present work investigates relations between fuel Reid vapor pressure (RVP) and biofuel (ethanol) content on stochastic preignition (SPI) at both sustained steady-state engine operation and following load transients.
Derek A. Splitter, Gurneesh Jatana, Dan DelVescovo, Gina Fioroni, Elana Chapman, John Salyers, Johnathan Pung, Scott Parrish   +7 more
doaj   +1 more source