Results 201 to 210 of about 2,680,718 (334)

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Effect of Changes in Plastic Flow During Non-Steady State Deformation on Force Behavior in Micro-Extrusion of Pure Copper. [PDF]

Materials (Basel)
Sugiyama K, Ito M, Yaguchi K, Funazuka T, Shiratori T.   +4 more
europepmc   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Adiponectin levels during steady state and vaso-occlusive crisis in Nigerian children with sickle cell anaemia. [PDF]

Ann Hematol
Ulasi AE, Nri-Ezedi CA, Okpara HC, Ikefuna A, Ulasi TO.   +4 more
europepmc   +1 more source

Steady-State [PDF]

, 2020
openaire   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Characterisation of steady-state pharmacokinetics and glucodynamics of once-weekly insulin efsitora alfa in individuals with type 2 diabetes. [PDF]

Diabetes Obes Metab
Leohr J, Klein O, Heise T, Zijlstra E, Bue-Valleskey JM, Suriyapperuma S, Jarrett R, James D, Case M, Waters D, Pratt E, Linnebjerg H.   +11 more
europepmc   +1 more source

Decision letter: Quantitative regulation of the dynamic steady state of actin networks

, 2018
Pekka Lappalainen, R. Dyche Mullins
openalex   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Incidence, Persistence, and Steady-State Prevalence in Coding Intensity for Health Plan Payment. [PDF]

Health Serv Res
McGuire TG, Enache OM, Chernew M, McWilliams JM, Nham T, Rose S.   +5 more
europepmc   +1 more source