Results 241 to 250 of about 18,641,062 (303)

The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity

FEBS Open Bio, EarlyView.
Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav, Shweta Shweta, Manisha Malhotra, Vikash Maurya, Akhilesh Kumar   +4 more
wiley   +1 more source

A Retrospective Within-Subjects Analysis of Vancomycin Bayesian Modeling With Pre-steady-State vs Steady-State Concentrations. [PDF]

J Pharm Technol
Covington EW, Chae JL, Gunter SG.
europepmc   +1 more source

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

FEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata, Yuxin Li, Kei Endo, Koichi Ito   +3 more
wiley   +1 more source

Atomic elementary flux modes explain the steady state flow of metabolites in large-scale flux networks. [PDF]

Cell Rep Methods
Chitpin JG, Perkins TJ.
europepmc   +1 more source

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

Effect of triazine thiols on steady-state mRNA levels in iPSC-derived hepatocytes. [PDF]

MicroPubl Biol
Martinez-Morant C, Liu JT, Jiang YL, Blaszkiewicz J, Duncan SA.   +4 more
europepmc   +1 more source

Recent insights into the molecular mechanism of ubiquinol oxidation by cytochrome bc1

FEBS Open Bio, EarlyView.
The review reflects on the mechanism of the catalytic reaction in cytochrome bc1: the electron bifurcation that involves the separation of two electrons derived from the quinol oxidation to opposite sides of the enzyme across the membrane. This review summarizes the long‐standing effort to understand the mechanism of quinol oxidation catalyzed by ...
Anna Wójcik‐Augustyn, Artur Osyczka, Marcin Sarewicz   +2 more
wiley   +1 more source

Probing Steady-State Carrier Properties and Charge Transport in Covalent Organic Framework by Frequency-Domain Terahertz Spectroscopy. [PDF]

Angew Chem Int Ed Engl
Nath S, Rout S, Samal M, Haldankar S, Ahsan MH, Mondal A, Tiwari S, Puthukkudi A, Kv A, Nandy AK, Prabhu SS, Biswal HS, Feng X, Biswal BP.   +13 more
europepmc   +1 more source

Post-translational negative feedback loops are sufficient to coordinate synthesis of the gram-negative envelope during steady-state growth. [PDF]

mBio
Beije J, Bokinsky G.
europepmc   +1 more source

Physics-Guided Neural Network for Quantitative Parameter Mapping Using Balanced Steady State Free Precession MRI. [PDF]

Magn Reson Med
Choi HR, Luu HM, Park SH.
europepmc   +1 more source