Results 261 to 270 of about 28,220,041 (343)

Clinical and laboratory characteristics of adolescents and young adults with sickle cell disease at steady state in Uganda. [PDF]

PLOS Glob Public Health
Ssekandi AM, Namazzi R, Muwonge H, Kalyesubula R, Munabi IG, Sekaggya-Wiltshere C, Namaganda A, Kimuli I, Akugizibwe R, Kasujja H, Mukunya D, Ndeezi G, Kiguli S.   +12 more
europepmc   +1 more source

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

FEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata, Yuxin Li, Kei Endo, Koichi Ito   +3 more
wiley   +1 more source

Steady-state mobilization with on-demand plerixafor after CD38 antibody-based induction in multiple myeloma patients. [PDF]

Transfusion
Röhnert MA, Seifert A, Trautmann-Grill K, Röllig C, Zimmer K, Egger-Heidrich K, Bill M, Heberling L, Schulze F, Blechschmidt M, von Bonin M, Bornhäuser M, Hölig K, Teipel R.   +13 more
europepmc   +1 more source

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

Activating plasmonic catalysis through light-mediated steady-state spin modulation. [PDF]

Nat Commun
Hu X, Liu J, Zhu Z, Liu S, Wang L, Cheng J, Huang X, Li C, Feng K, Zhou Y, Xu Y, Feng Q, Zhang B, Chen X, Zhang L, Zhang Q, Wu B, Yin J, An X, Zhang XH, He L.   +20 more
europepmc   +1 more source

Recent insights into the molecular mechanism of ubiquinol oxidation by cytochrome bc1

FEBS Open Bio, EarlyView.
The review reflects on the mechanism of the catalytic reaction in cytochrome bc1: the electron bifurcation that involves the separation of two electrons derived from the quinol oxidation to opposite sides of the enzyme across the membrane. This review summarizes the long‐standing effort to understand the mechanism of quinol oxidation catalyzed by ...
Anna Wójcik‐Augustyn, Artur Osyczka, Marcin Sarewicz   +2 more
wiley   +1 more source

A steady-state approach for analysis of high-resolution relaxometry. [PDF]

J Magn Reson
Bhattacharya S, Goger M, Dahmane T, Palmer AG.   +3 more
europepmc   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

ATP-dependent actin barbed-end fluctuations at steady state. [PDF]

Proc Natl Acad Sci U S A
Duttagupta M, Riley AT, Brieher WM.
europepmc   +1 more source

Five‐Year Outcomes of Laparoscopic Sphincter‐Preserving Surgery for Rectal Cancer: A Prospective Study in Elderly Vietnamese Patients

Aging and Cancer, EarlyView.
This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho, Quang Le, Ngoc Thach Tran, Van Viet Ung, Loc Vu   +4 more
wiley   +1 more source