Results 71 to 80 of about 37,370,397 (253)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Quantitative in silico analysis of neurotransmitter pathways under steady state conditions

Frontiers in Endocrinology, 2013
The modeling of glutamate/GABA-glutamine cycling in the brain tissue involving astrocytes, glutamatergic, and GABAergic neurons leads to a complex compartmentalized metabolic network that comprises neurotransmitter synthesis, shuttling, and degradation ...
Erkki eSomersalo, Daniela eCalvetti
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Alternative Transient and Steady State Analysis of Some Gaver’s Parallel Systems [PDF]

International Journal of Mathematical, Engineering and Management Sciences
This paper presents one of the most interesting generalizations of Gaver’s basic two-unit parallel system sustained by a cold standby unit and attended by a repairman with multiple vacations.
Ramaz Khurodze, Revaz Kakubava, Murman Kublashvili, Teimuraz Saghinadze   +3 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Analogue mouse pointer control via an online steady state visual evoked potential (SSVEP) brain-computer interface [PDF]

, 2011
The steady state visual evoked protocol has recently become a popular paradigm in brain–computer interface (BCI) applications. Typically (regardless of function) these applications offer the user a binary selection of targets that perform correspondingly
Ramaswamy Palaniappan, John J Wilson, Wilson, John J., Palaniappan, Ramaswamy   +3 more
core   +1 more source

Steady-state Analysis of Doubly-fed Wind Power Generator

Kongzhi Yu Xinxi Jishu, 2010
It introduces the steady-state analysis of doubly-fed wind power generator based on the work conditions and the equivalent circuit, reckons the calculation process of the current on both stator side and rotor side.
郁灿, 金新民, 张禄, 战亮宇
doaj  

The Impact of Solar Power Plants on the Electricity Grid: A Case Study of Albania

Eng
The demand for electricity in Albania has risen significantly in recent years, accompanied by a growing emphasis on sustainable and environmentally friendly development.
Astrit Bardhi, Ajakida Eski, Bajram Leka, Klodian Dhoska   +3 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source