Results 91 to 100 of about 539,119 (298)

Gas phase production of NHD2 in L134N [PDF]

, 2001
We show analytically that large abundances of NH2D and NHD2 can be produced by gas phase chemistry in the interiors of cold dense clouds. The calculated fractionation ratios are in good agreement with the values that have been previously determined in ...
Adams N. G., Brown P. D., Brown P. D., Ceccarelli C., Gerin M., Guelin M., Larsson M., Le Bourlot J., Le Bourlot J., Loinard L., Marquette J. B., Millar T. J., Olberg M., Opendak M., Roberts H., Rodgers S. D., Roueff E., S. B. Charnley, S. D. Rodgers, Sidhu K. S., Tielens A. G. G. M., Tine S., Ungerechts H., Vikor L.   +23 more
core   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Interstellar chemistry of nitrogen hydrides in dark clouds [PDF]

, 2013
The aim of the present work is to perform a comprehensive analysis of the interstellar chemistry of nitrogen, focussing on the gas-phase formation of the smallest polyatomic species and in particular nitrogen hydrides.
Faure, Alexandre, Forêts, Guillaume Pineau des, Gal, Romane Le, Hily-Blant, Pierre, Maret, Sébastien, Rist, Claire   +5 more
core   +3 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

The micro-optical ring electrode Part 2 : theory for the transport limited, steady-state photocurrent. [PDF]

, 2006
The micro-optical ring electrode (MORE) is a photoelectrochemical device based on a ring microelectrode that uses the insulating material interior to the ring electrode as a light guide.
Andrieux, Fabrice Pierre Louis, Boxall, C., O'Hare, D.   +2 more
core   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

The Chemistry of Interstellar OH+, H2O+, and H3O+: Inferring the Cosmic Ray Ionization Rates from Observations of Molecular Ions

, 2012
We model the production of OH+, H2O+, and H3O+ in interstellar clouds, using a steady state photodissociation region code that treats the freeze-out of gas species, grain surface chemistry, and desorption of ices from grains.
Badnell, Bakes, Cartledge, D. Neufeld, Dalgarno, David Hollenbach, Draine, Goicoechea, Goicoechea, Habing, Heiles, Heiles, Hollenbach, Indriolo, Indriolo, J. R. Goicoechea, Jensen, Jensen, Jochims, Joulain, Krełowski, Le Petit, M. J. Kaufman, M. Wolfire, Mathis, Meyer, Rimmer, Sofia, Weingartner, Weingartner, Wolfire, Wolfire   +31 more
core   +1 more source

Symbolic construction of the chemical Jacobian of quasi-steady state (QSS) chemistries for Exascale computing platforms

Combustion and Flame
The Quasi-Steady State Approximation (QSSA) can be an effective tool for reducing the size and stiffness of chemical mechanisms for implementation in computational reacting flow solvers. However, for many applications, stiffness remains, and the resulting model requires implicit methods for efficient time integration.
Malik Hassanaly, Nicholas T. Wimer, Anne Felden, Lucas Esclapez, Julia Ream, Marc T. Henry de Frahan, Jon Rood, Marc Day   +7 more
openaire   +2 more sources

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source