Results 101 to 110 of about 513,877 (318)

Photophysics and Photochemistry of Canonical Nucleobases’ Thioanalogs: From Quantum Mechanical Studies to Time Resolved Experiments

Molecules, 2017
Interest in understanding the photophysics and photochemistry of thiated nucleobases has been awakened because of their possible involvement in primordial RNA or their potential use as photosensitizers in medicinal chemistry.
Serra Arslancan, Lara Martínez-Fernández, Inés Corral   +2 more
doaj   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

Oxidative stress: a concept in redox biology and medicine

Redox Biology, 2015
“Oxidative stress” as a concept in redox biology and medicine has been formulated in 1985; at the beginning of 2015, approx. 138,000 PubMed entries show for this term. This concept has its merits and its pitfalls. Among the merits is the notion, elicited
Helmut Sies
doaj   +1 more source

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

Molecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair, Philip König, Milena Mijović, Jessica Kalla, Anil Baskan, Loan Tran, Kristina Draganić, Pedro Morata Saldaña, Carlos Uziel Pérez Malla, Janette Pfneissl, Andreas Tiefenbacher, Julijan Kabiljo, Velina S. Atanasova, Lisa Wozelka‐Oltjan, Leonhard Müllauer, Michael Bergmann, Raheleh Sheibani‐Tezerji, Gerda Egger   +17 more
wiley   +1 more source

Interstellar deuterated ammonia: From NH3 to ND3

, 2005
We use spectra and maps of NH2D, ND2H, and ND3, obtained with the CSO, IRAM 30m and Arecibo telescopes, to study deuteration processes in dense cores. The data include the first detection of the hyperfine structure of ND2H.
Anglada, Bachiller, Bacmann, Bacmann, Caselli, Caselli, Ceccarelli, Ceccarelli, D. C. Lis, Dartois, Dartois, E. Roueff, F. F. S. van der Tak, Flower, Geppert, Gerin, Gerlich, Gerlich, Gibb, Hatchell, Hirota, Hirota, Jacq, Jijina, Le Bourlot, Linsky, Lis, Lis, Loinard, M. Gerin, Marcelino, Marquette, McCall, McMullin, Mizuno, P. F. Goldsmith, Pagani, Parise, Parise, Parise, Pontoppidan, Roberts, Roberts, Roberts, Rodgers, Roueff, Roueff, Roueff, Shah, Smith, Stark, Stark, Tielens, Tiné, Turner, Turner, Ungerechts, van der Tak, van Veldhoven, Vastel, Vastel, Walmsley, Watson, Öjekull   +63 more
core   +2 more sources

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Kemi, paracelsism och mekanisk filosofi

Lychnos, 2008
The paper attempts to thoroughly revise the traditional view of Swedish chemistry prior to the 1770s. Emphasis is laid on the two central nodes of the Swedish chemical and mineralogical tradition: the state Board of Mines and Uppsala University.
Hjalmar Fors
doaj  

Investigation of Cycle-to-Cycle Variability of NO in Homogeneous Combustion

Oil & Gas Science and Technology, 2015
Cyclic variability of spark ignition engines is recognized as a scatter in the combustion parameter recordings during actual operation in steady state conditions. Combustion variability may occur due to fluctuations in both early flame kernel development
Karvountzis-Kontakiotis A., Ntziachristos L.   +1 more
doaj   +1 more source

Toward Multi-Parametric Porous Silicon Transducers Based on Covalent Grafting of Graphene Oxide for Biosensing Applications

Frontiers in Chemistry, 2018
Graphene oxide (GO) is a two-dimensional material with peculiar photoluminescence emission and good dispersion in water, that make it an useful platform for the development of label-free optical biosensors. In this study, a GO-porous silicon (PSi) hybrid
Rosalba Moretta, Rosalba Moretta, Monica Terracciano, Principia Dardano, Maurizio Casalino, Luca De Stefano, Chiara Schiattarella, Chiara Schiattarella, Ilaria Rea   +8 more
doaj   +1 more source

Mechanisms and kinetic assays of aminoacyl‐tRNA synthetases

FEBS Letters, EarlyView.
Igor Zivkovic, Morana Dulic, Ita Gruic‐Sovulj   +2 more
wiley   +1 more source