Results 121 to 130 of about 170,525 (342)

AI‐Assisted Drug Re‐Purposing for Human Liver Fibrosis

Advanced Science, EarlyView.
A multi‐agent AI (AI co‐scientist) is used to repurpose drugs for liver fibrosis treatment and to guide their experimental characterization. The anti‐fibrotic efficacy and toxicity of these drugs is assessed in multi‐lineage human hepatic organoids grown in microwells (microHOs).
Yuan Guan, Lu Cui, Jakkapong Inchai, Zhuoqing Fang, Jacky Law, Alberto Alonzo Garcia Brito, Annalisa Pawlosky, Juraj Gottweis, Alexander Daryin, Artiom Myaskovsky, Lakshmi Ramakrishnan, Anil Palepu, Kavita Kulkarni, Wei‐Hung Weng, Zhuanfen Cheng, Vivek Natarajan, Alan Karthikesalingam, Keran Rong, Yunhan Xu, Tao Tu, Gary Peltz   +20 more
wiley   +1 more source

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

Pimpinella anisum L. fruit: Chemical composition and effect on rat model of nonalcoholic fatty liver disease

Journal of Research in Medical Sciences, 2017
Background: Nonalcoholic fatty liver disease (NAFLD) includes a group of chronic liver disorders caused by irregular accumulation of fat in liver tissue.
Ali Asadollahpoor, Mohammad Abdollahi, Roja Rahimi   +2 more
doaj   +1 more source

New insights into the pathogenesis and treatment of non-viral hepatocellular carcinoma: a balancing act between immunosuppression and immunosurveillance. [PDF]

, 2018
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related deaths worldwide. HCC initiates as a consequence of chronic liver damage and inflammation caused by hepatitis B and C virus infections, excessive alcohol consumption, or non ...
Karin, Michael
core   +1 more source

Nutritional c‐Fos Induction Rewires Hepatic Metabolism and Can Promote Obesity‐Associated Hepatocellular Carcinoma

Advanced Science, EarlyView.
It is shown that hepatic c‐Fos responds to feeding, altering de novo lipogenesis, glycolysis, and a wide range of steatosis‐associated metabolic signaling pathways. Obesogenic diets cause hepatic c‐Fos overexpression, insulin resistance, and the induction of metabolic reprogramming‐related genes.
Ao Li, Eduardo H. Gilglioni, Wadsen St‐Pierre‐Wijckmans, Leila Hosseinzadeh, Christelle Veyrat‐Durebex, Sumeet Pal Singh, Roberto Coppari, Latifa Bakiri, Esteban N. Gurzov   +8 more
wiley   +1 more source

Functional condition of the stomach,pancreas, liver, ulcer and gall-bladder in celiac disease

Терапевтический архив, 2011
Aim. To study condition of the stomach, gall-bladder, pancreas, liver in celiac disease (CD) and contribution of their dysfunction to clinical presentation of CD symptoms. Material and methods.
Larisa Matisovna Krums, E A Sabel'nikova, Asfol'd Ivanovich Parfenov, L M Krums, E A Sabelnikova, A I Parfenov   +5 more
doaj  

Are transmembrane 6 superfamily member 2 gene polymorphisms associated with steatohepatitis after pancreaticoduodenectomy?

JGH Open
Aim After pancreaticoduodenectomy, 20–40% of patients develop steatotic liver disease (SLD), and steatohepatitis can be a problem. Although patatin‐like phospholipase domain‐containing 3 protein (PNPLA3) and transmembrane 6 superfamily member 2 (TM6SF2 ...
Tomotaka Mori, Eisuke Ozawa, Ryu Sasaki, Akane Shimakura, Kosuke Takahashi, Yoko Kido, Yasuko Kanda, Satoshi Matsuo, Kazuaki Tajima, Asami Beppu, Yasuhiko Nakao, Masanori Fukushima, Masafumi Haraguchi, Satoshi Miuma, Hisamitsu Miyaaki, Tomohiko Adachi, Susumu Eguchi, Shinji Okano, Kazuhiko Nakao   +18 more
doaj   +1 more source

Research landscape and frontiers of non-alcoholic steatohepatitis-associated hepatocellular carcinoma: a bibliometric and visual analysis [PDF]

, 2023
Bowen Gao, Zhiheng Chen, Meijie Shi, Yousheng Mo, Huanming Xiao, Yubao Xie, Ming Lin, Xiaoling Chi   +7 more
openalex   +1 more source

Effect of Wakame and Carob Pod Snacks on Non-Alcoholic Fatty Liver Disease [PDF]

, 2019
Snacks combining different functional ingredients could represent a useful therapeutic strategy against NAFLD. The present study aimed to analyze the effect of two snack formulations based on carob and wakame flour in the treatment for NAFLD in rats. For
Aguirre López, Leixuri, De Luis Román, Daniel Antonio, Lasa Elguezua, Arrate, Martín Diana, Ana Belén, Milton Laskibar, Iñaki, Miranda Gómez, Jonatan, Rico Bargues, Daniel   +6 more
core   +2 more sources

Ubc9‐Mediated SUMOylation of RPL3, an Unappreciated Mechanism against Hepatocyte Senescence by Repressing the DHX9‐p16 Axis

Advanced Science, EarlyView.
Liver aging is characterized by a decline in the expression of the SUMO‐conjugating enzyme Ubc9, resulting in reduced SUMOylation levels in hepatocytes, particularly in the case of ribosomal protein RPL3. Disruption of RPL3 SUMOylation increases its nuclear translocation. Interestingly, ribosome‐free RPL3 facilitates the recruitment of helicase DHX9 to
Hao Xie, Zhichao Gao, Xin Liu, Shiyi Zhang, Yuhan Wang, Jia Gao, Ping Qi, Lu Zhang, Jiawei Zhao, Tian Xiong, Teng Huang, Jia Song, Qilin Yu, Shu Zhang, Yanjun Liu, Ping Yang, Maryam S. Al‐Motawa, Quan Gong, Junfeng Dong, Hao Yin, Fei Sun, Shiwei Liu, Cong‐Yi Wang   +22 more
wiley   +1 more source