Results 241 to 250 of about 125,716 (297)

Metabolic Disorders and Complications. [PDF]

Diabetes Metab Syndr Obes
Sull JW, McClain DA.
europepmc   +1 more source

Is AMP‐activated protein kinase activation a central mechanism of cardio‐metabolic outcomes after metabolic and bariatric surgery?

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Metabolic and bariatric surgery (MBS) is the most effective treatment for severe obesity. It usually results in spectacular weight loss, associated with improvements of obesity‐associated comorbidities. The mechanisms underlying these benefits are not fully understood but could involve a postoperative activation of the enzyme 5′ AMP‐activated ...
Adrien Delcour, Nathalie Niederhoffer
wiley   +1 more source

A Phase 2a Trial of Myeloperoxidase Inhibitor Mitiperstat in Non-Cirrhotic Metabolic Dysfunction-Associated Steatohepatitis. [PDF]

Liver Int
Armisen J, Flor A, Eriksson J, Nelander K, Bhattacharya CS, Sunnåker M, Carter D, Trebski M, Gårdmark E, Aurell M, Whatling C, Challis B, Vespasiani-Gentilucci U, COSMOS Investigators.   +13 more
europepmc   +1 more source

The depletion of serine beta‐lactamase‐like protein (LACTB) ameliorates metabolic dysfunction–associated steatotic liver disease by reducing ubiquitin‐mediated degradation of carnitine palmitoyltransferase 2

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Aims Metabolic dysfunction–associated steatotic liver disease (MASLD) represents one of the most common chronic liver disorders worldwide, and its incidence continues to rise each year. Serine β‐lactamase‐like protein (LACTB) is a serine protease that plays a crucial role in lipid metabolism and hepatocellular carcinoma, but its function in ...
Wujiang Shi, Xin Liu, Nan Wang, Qianwen Zhang, Jianjun Gao, Canghai Guan, Yapeng Li, Chengru Yang, Shaowu Bi, Xinlei Zou, Xiangyu Zhong   +10 more
wiley   +1 more source

The role of insulin resistance in nonalcoholic steatohepatitis and liver disease development – a potential therapeutic target?

, 2015
Paola Dongiovanni, Raffaela Rametta, Marica Meroni, Luca Valenti   +3 more
openalex   +2 more sources

Transglutaminase‐mediated cytokeratin modifications implicated in bile‐acid‐induced hepatocyte death

The FEBS Journal, EarlyView.
Cholestasis and bile‐acid exposure enhance expression and activity of protein crosslinking enzymes TG1 and TG2 in hepatocytes. Substrate proteins were identified by mass spectrometry using biotin‐labeled peptides (pepK5/pepT26) or amine donor (biotinylated pentylamine; BPA). Crosslinking‐induced aggregation and fragmentation of keratin 18 and 8 (K18/K8)
Hideki Tatsukawa, Haruka Nakagawa, Chin Mun Yee, Keiko Kuwata, Kiyotaka Hitomi   +4 more
wiley   +1 more source

Therapeutic Potential of Quercetin, Silibinin, and Crocetin in a High-Fat Diet-Induced Mouse Model of MASLD: The Role of CD36 and PLIN3. [PDF]

Life (Basel)
Sotiropoulou M, Katsaros I, Vailas M, Papachristou F, Papakyriakopoulou P, Kostomitsopoulos N, Giatromanolaki A, Valsami G, Tsaroucha A, Schizas D.   +9 more
europepmc   +1 more source

Type 2 Diabetes Mellitus Complicated with Smoldering Myeloma and Non-alcoholic Steatohepatitis

, 2005
Takehiro Nakahara, Toshihiro Utsugi, Yoshio Ohyama, Shoichi Tomono, Ken Sato, Hitoshi Takagi, Hirokazu Murakami, Akira Hasegawa, Masahiko Kurabayashi   +8 more
openalex   +2 more sources

Artificial lipidation of proteins and peptides: from mechanism to clinical applications

The FEBS Journal, EarlyView.
Artificial lipidation transforms protein and peptide therapeutics by attaching fatty acid chains through reversible or permanent chemical strategies. This biomimetic approach delivers four key therapeutic advantages: extended circulation times (enabling weekly instead of daily dosing), alternative administration routes including oral delivery, precise ...
Jiaming Mu, Emily Vong, Sheiliza Carmali
wiley   +1 more source

Correction for Sakuma et al., Liver lipid droplet cholesterol content is a key determinant of metabolic dysfunction-associated steatohepatitis. [PDF]

Proc Natl Acad Sci U S A
europepmc   +1 more source