Results 81 to 90 of about 125,716 (297)

Letter to the Editor: LO2, a misidentified cell line: Some data should be interpreted with caution

, 2022
Hepatology, EarlyView.
Ralf Weiskirchen
wiley   +1 more source

Non-Alcoholic Steatohepatitis: A Review of Its Mechanism, Models and Medical Treatments

Frontiers in Pharmacology, 2020
Non-alcoholic steatohepatitis (NASH) develops from non-alcoholic fatty liver disease (NAFLD). Currently, around 25% of the population is estimated to have NAFLD, and 25% of NAFLD patients are estimated to have NASH.
C. Peng, A. Stewart, O. Woodman, R. Ritchie, C. Qin   +4 more
semanticscholar   +1 more source

The Regulatory Role of Iron Transporter SLC39A13 in Liver Fibrosis

Advanced Science, EarlyView.
SLC39A13/ZIP13, a newly discovered intracellular iron transporter, delivers iron to the ER/Golgi to catalyze procollagen hydroxylation during collagen maturation. Here, we systematically characterize the cell type‐specific functions of ZIP13 across distinct hepatic cell populations, and identify hepatic stellate cell‐specific ZIP13 as a promising and ...
Shanshan Guo, Yalin Wang, Binyu Lu, Yu Zhang, David M. Frazer, Bing Zhou   +5 more
wiley   +1 more source

RENAL INJURY AND METABOLIC DYSFUNCTION-ASSOCIATED STEATOTIC LIVER DISEASE IN PATIENTS WITH OBESITY [PDF]

Arquivos de Gastroenterologia
Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) is currently the most prevalent cause of chronic hepatic disease worldwide.
Kellyane Dias CARVALHO, Cláudia DALTRO, Carla DALTRO, Helma Pinchemel COTRIM   +3 more
doaj   +1 more source

The Role of Epigenetic Changes in the Progression of Alcoholic Steatohepatitis [PDF]

, 2021
Hyeong Geug Kim, Jung-Hyo Cho, Jeongkyu Kim, Seung-Jin Kim   +3 more
openalex   +1 more source

OCTN2 Activates a Non‐Canonical Carnitine Metabolic Pathway to Promote MASH‐HCC Progression and Immunotherapy Resistance

Advanced Science, EarlyView.
In non‐MASH‐HCC, L‐carnitine promotes tumor progression primarily through its classical role in enhancing fatty acid oxidation (FAO). However, in MASH‐HCC, where FAO is markedly suppressed, L‐carnitine shifts from this canonical function to serve instead as an intracellular acetyl group buffer.
Chuqi Xia, Xiao Zhang, Jinze Li, Ning Xu, Sheng Hu, Qiyu Lu, Yuxuan Li, Taifu Xiao, Xu Li, Xue Wang, Kequan Xu, Daoming Liang   +11 more
wiley   +1 more source

DIETARY FOOD FORTIFIED WITH OROTIC ACID AND LIVER FUNCTION

Makara Seri Sains, 2011
The effects of dietary food fortified with orotic acid (1.0%) on liver function were studied in rats. The rats fed withorotic acid promoted liver triglyceride content markedly, that was 5-fold higher than that of the control.
Yohanes Buang
doaj  

Efficacy of human placenta hydrolyzate in the treatment of patients with metabolic associated fatty liver disease at the stage of fibrosis (pilot study)

Терапевтический архив
Background. Despite active research, drug treatment options for metabolic associated fatty liver disease (MAFLD) are limited, and there are no currently approved drugs for patients with MAFLD.
Elena V. Vinnitskaya, Yuliay G. Sandler, Kirill G. Saliev, Anton N. Ivanov, Evgenia S. Sbikina, Tatyana Yu. Khaymenova, Dmitry S. Bordin   +6 more
doaj   +1 more source

Hepatic Macrophages as Targets for the MSC-Based Cell Therapy in Non-Alcoholic Steatohepatitis [PDF]

, 2023
И. В. Холоденко, K. N. Yarygin   +1 more
openalex   +1 more source

Integrin β3 Orchestrates Hepatic Steatosis via a Novel CD36‐Dependent Lipid Uptake Complex

Advanced Science, EarlyView.
In MASH, ITGB3 recruits LYN and drives its ubiquitin‐proteasomal degradation via phosphorylation. This relieves DHHC5 inhibition, enabling ITGB3/DHHC5/CD36 complex assembly to enhance CD36 palmitoylation and fatty acid uptake, thereby exacerbating disease. Targeting ITGB3 blocks this pathogenic axis and ameliorates MASH.
Ying Zhang, Lei Dai, Zhongquan Cui, Ye Zhou, Wenyuan Dong, Hongcheng Jiang, Mengwen Wang, Xiaodan Zhong, Wei Dong, Zhang Yue, Thati Madhusudhan, Hongjie Wang, Xiong Zhong Ruan, Hesong Zeng   +13 more
wiley   +1 more source