Results 291 to 300 of about 198,724 (360)

Oleic Acid Increases Lipid Accumulation in Duck Hepatocytes by Promoting Apolipoprotein A1 Expression. [PDF]

Animals (Basel)
Pan Z, Li X, Wu D, Xie L, Chen X, Geng Z.   +5 more
europepmc   +1 more source

Circular RNAs: Epigenetic Puppeteers Pulling the Strings of Cancer Pathogenesis

Medicine Bulletin, EarlyView.
ABSTRACT Circular RNAs (circRNAs), a unique class of endogenous noncoding RNAs characterized by their covalently closed loop structure, have emerged as pivotal players in cancer biology due to their exceptional stability, tissue‐specific expression, and diverse regulatory functions.
Yimao Wu, Zichang Chen, Junying Lee, Gokhan Zengin, Meng‐Yao Li   +4 more
wiley   +1 more source

Human Cyclophilins—An Emerging Class of Drug Targets

Medicinal Research Reviews, EarlyView.
ABSTRACT Cyclophilins are a family of enzymes with peptidyl‐prolyl isomerase activity found in all cells of all organisms. To date, 17 cyclophilin isoforms have been identified in the human body, participating in diverse biological processes. Consequently, cyclophilins have emerged as promising targets for drug development to address a wide array of ...
Katarina Jurkova, Hana Navratilova, Kamil Musilek, Ondrej Benek   +3 more
wiley   +1 more source

Validation of Intravoxel Incoherent Motion MRI Using Perfused Explanted Human Livers

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose Evaluate the feasibility of using perfused explanted human livers for validating intravoxel incoherent motion (IVIM). Methods Eight (n = 8) explanted livers from deceased donors were obtained. The portal vein and hepatic artery of each explanted liver were connected to a perfusion system.
Gregory Simchick, James Rice, Leah M. Gober, Daniel Rice, Jennifer Philip, Alejandro Roldan‐Alzate, Diego Hernando   +6 more
wiley   +1 more source

Highly Reproducible, Vendor‐Agnostic, Motion‐Insensitive Liver PDFF Mapping at 0.55T, 1.5T, and 3T

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose To develop and validate a vendor‐agnostic, motion‐insensitive proton‐density fat‐fraction (PDFF) quantification method. Methods Flip‐angle‐modulated (FAM) 2D chemical‐shift‐encoded (CSE) MRI for PDFF quantification was implemented in both the vendor‐agnostic platform Pulseq (“Pulseq‐FAM”) and one vendor‐specific platform (“GE‐specific ...
Jiayi Tang, Daiki Tamada, Jon‐Fredrik Nielsen, Jitka Starekova, Julius F. Heidenreich, Felix Schön, Alexandra A. Anagnostopoulos, Amirhossein Roshanshad, Lu Mao, Shohei Fujita, Pengcheng Xu, Christopher Keen, Imam Ahmed Shaik, Eugene Milshteyn, Seonghwan Yee, Andrew J. Ellison, David Rutkowski, Jeff Kammerman, Jean H. Brittain, Xiaodong Zhong, William A. Grissom, Maxim Zaitsev, Aaron L. Carrel, Yogesh Rathi, Yun Jiang, Berkin Bilgic, Scott B. Reeder, Diego Hernando   +27 more
wiley   +1 more source

Liver Steatosis in Induced Hepatocytes From Carriers of Spinal Muscular Atrophy

Muscle &Nerve, EarlyView.
ABSTRACT Introduction/Aims Although classically characterized as a motor neuron disease, spinal muscular atrophy (SMA) is increasingly recognized as a multisystem disorder. We previously showed hepatocyte‐intrinsic steatosis in SMA, raising the question of whether SMA carriers, who are typically asymptomatic, may also exhibit subclinical hepatic ...
Lingyu Sun, Damien Meng Kiat Leow, Loo Chien Wang, Michelle Yating Eio, Hiromi W. L. Koh, Zi Jian Khong, Gunaseelan Narayanan, Aloysius Kai Soon Teo, Richard Giadone, Radoslaw M. Sobota, Shi Yan Ng, Adrian Kee Keong Teo, Wei Yi Ong, Lee L. Rubin, Basil T. Darras, Crystal J. J. Yeo   +15 more
wiley   +1 more source

Prevalence of Nonalcoholic Fatty Liver Disease in Obese Patients and its Association with Insulin Resistance Markers.

J Pharm Bioallied Sci
Nayak J, Luke NE, Deshpande AV, Gupta S, Saiyad H, Farooqui S.   +5 more
europepmc   +1 more source

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Pancreatic steatosis

Current Opinion in Gastroenterology, 2019
Pancreatic steatosis is a clinical entity with emerging significance and impacts patient health in a multitude of ways. It has a high prevalence in the global population with predilections for different demographics by age, sex and ethnicity. Understanding the pathophysiology, clinical features and complications of this entity may be important to ...
Resham, Ramkissoon, Timothy B, Gardner
openaire   +2 more sources

Mirtazapine-induced steatosis

Int. Journal of Clinical Pharmacology and Therapeutics, 2017
Mirtazapine is a commonly used drug indicated for the treatment of severe depression. It works as a presynaptic α2-adrenoreceptor antagonist that increases central noradrenergic and serotonergic neurotransmission, and it is metabolized by the p450 cytochrome oxidase system.
Elin, Thomas, Hasan, Haboubi, Namor, Williams, Aled, Lloyd, Chin Lye, Ch'ng   +4 more
openaire   +2 more sources