Results 61 to 70 of about 2,700,991 (344)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Experimental Studies on Punching Shear and Impact Resistance of Steel Fibre Reinforced Slag Based Geopolymer Concrete

Advances in Civil Engineering, 2017
The study was focused on slag based geopolymer concrete with the addition of steel fibre. The slag based geopolymer concrete was under shear load and sudden impact load to determine its response.
Srinivasan Karunanithi
doaj   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Behaviour of Stainless-Steel Fibre-Reinforced Exterior Beam-Column Joints under Reverse Cyclic Loading

Advances in Civil Engineering, 2023
The objective of this study is to evaluate the flexural behaviour of stainless-steel fibre-reinforced concrete beam-column (BC) joints under reverse cyclic loading.
Palaniappan Prasath, Balaji Shanmugam, Paul Awoyera   +2 more
doaj   +1 more source

Experimental Investigation on the Axial Compressive Behaviour of Cold-Formed Steel-Concrete Composite Columns Infilled with Various Types of Fibre-Reinforced Concrete

Buildings, 2023
The exceptional structural strength and low cost of steel-concrete composite columns make them a popular choice for civil engineering structures. Numerous forms of composite columns, including steel tubes filled with concrete, have been produced recently
Florence More Dattu Shanker More, Senthil Selvan Subramanian   +1 more
doaj   +1 more source

Early Clinical, Imaging, and Pathological Characteristics of SRPK3/TTN‐Digenic Myopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SRPK3/TTN‐digenic myopathy was recently established as a skeletal muscle myopathy caused by digenic inheritance. This study characterizes the early clinical presentation of SRPK3/TTN‐digenic myopathy in one previously reported and seven newly identified pediatric patients.
Rotem Orbach, Sandra Donkervoort, Carola Hedberg‐Oldfors, Giovanni Baranello, Dimah Saade, Precilla D'Souza, Ruchee Patel, Eva Michael, A. Reghan Foley, Diana Bharucha‐Goebel, S. Jin Haugland, Meghan McAnally, Omer Abdul Hamid, Katherine Chao, Ellen F. Macnamara, Alan H. Beggs, Anna Sarkozy, Juliane Mueller, Steven A. Moore, Richard S. Finkel, Cynthia J. Tifft, Francesco Muntoni, Anders Oldfors, Carsten G. Bönnemann   +23 more
wiley   +1 more source

Impact of Steel Fibre Reinforcement on the Strength of Steel Anchors

IOP Conference Series: Materials Science and Engineering, 2020
Abstract The paper presents methods of fastening using expansion fasteners and concrete screws anchored in conventional concrete and in fibre reinforced concrete. It addresses ways to determine the strength of such joints based on the EOTA (European Organisation for Technical Assessment) Guidelines and US Recommendations.
Daniel Dudek, Kazimierz Konieczny
openaire   +1 more source

Freeze-thaw resistance of steel fibre reinforced rubberised concrete

Construction and Building Materials, 2019
This study evaluates the freeze-thaw performance of steel fibre reinforced rubberised concretes (SFRRuC) engineered for flexible concrete pavements. The effect of large volumes of fine and coarse rubber particles (i.e.
Abdulaziz S. Alsaif, S. Bernal, M. Guadagnini, K. Pilakoutas   +3 more
semanticscholar   +1 more source

MOGAD Is the Most Common Cause of Isolated Optic Neuritis in Children

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives The study aimed to characterize the clinical features, etiologies, and outcomes of isolated, first‐time pediatric ON in the post‐MOG‐IgG era. Methods This was a single‐center retrospective cohort study at Texas Children's Hospital of patients diagnosed with first‐time ON between 2018–2024, with follow‐up data collected through 2025.
Chaitanya Aduru, Akansha Chandrasekar, Kyla Blasingame, Jonathan Rosen, Jesse M. Levine, Karla Salazar, Madhuri Chilakapati, Rod Foroozan, Victoria Hardwick, Jonathan M. Yarimi, Nikita Shukla, Timothy E. Lotze, Kristen S. Fisher, Alexander J. Sandweiss   +13 more
wiley   +1 more source