Results 91 to 100 of about 224,077 (308)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Frictional and structural characterization of ion-nitrided low and high chromium steels [PDF]

Low Cr steels AISI 41410, AISI 4340, and high Cr austenitic stainless steels AISI 304, AISI 316 were ion nitrided in a dc glow discharge plasma consisting of a 75 percent H2 - 25 percent N2 mixture.
Spalvins, T.
core   +1 more source

In situ observation of strain and phase transformation in plastically deformed 301 austenitic stainless steel [PDF]

, 2016
To inform the design of superior transformation-induced plasticity (TRIP) steels, it is important to understand what happens at the microstructural length scales.
Abreu, Bachmann, Bain, Bhadeshia, Bhadeshia, Bolling, Bouguet, Bowles, Bunge, Cakmak, Chatterjee, Cherkaoui, Clocksin, Delogu, Di Gioacchino, Dieter, Ferreira, Frank, Geijselaers, Gey, Gioacchino, Guimarães, Kammers, Kato, Kundu, Kundu, Kundu, Kurdjumov, LaVision, Lecroisey, Lim, Lucas, Mackenzie, McMurtrey, Moat, Olson, Olson, Olson, Patel, Patriarca, Roters, Sachs, Schreier, Simm, Simm, Sutton, Takahashi, Talonen, Talonen, Tasan, Taylor, Tsuchida, Tsuchida, Yeddu, Zackay   +54 more
core   +2 more sources

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Solidification characteristics of Fe-Ni peritectic alloy thin strips under a near-rapid solidification condition [PDF]

China Foundry, 2015
This paper is an experimental investigation of the structure evolution and the solute distribution of 2 mm thick strips of Fe-(2.6, 4.2, 4.7, 7.9wt.%)Ni peritectic alloy under a near-rapid solidification condition, which were in the regions of δ-ferrite ...
Chang-jiang Song, Yang Yang, Yuan-yi Guo
doaj  

Frame-Based Knowledge Representation [PDF]

, 1978
This report describes research done at the Artificial Intelligence Laboratory of the Massachusetts Institute of Technology. The author was sponsored by the Institute of International Education on an ITT-fellowship.The paper introduces a language for ...
Steels, Luc
core  

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Exploration of microstructural evolution and corrosion behavior of 254 SMO super-austenitic stainless steel bipolar plates following high-speed tensile deformation

Journal of Materials Research and Technology
This study examined the influence of high-speed tensile deformation on the microstructure evolution and corrosion behavior of novel 254 SMO super-austenitic stainless steel (SASS) bipolar plates in a simulated cathode environment for proton exchange ...
Bingbing Li, Yuping Lang, Haitao Chen, Hanqiu Feng, Zhijun Gao   +4 more
doaj   +1 more source