Results 131 to 140 of about 5,076 (216)

Out in the cold? A review of Early Middle Palaeolithic settlements in northern Central Europe, age data and geological preconditions for site formation and preservation

open access: yesBoreas, EarlyView.
The characteristics of settlement of Neanderthals in northern Central Europe during the earlier phases of the Middle Palaeolithic (Marine Isotope Stage 8–6) have been a matter of debate for decades, specifically regarding the population dynamics at such latitudes during the coldest phases. In this paper, we review the known archaeological record of the
Gianpiero Di Maida   +5 more
wiley   +1 more source

Late Holocene moisture variability in Arctic Alaska from chitin δ18O

open access: yesBoreas, EarlyView.
Amplified warming in the Arctic has resulted in reduced sea‐ice extent, which can impact regional climate dynamics. Elucidating past moisture variability in response to changing temperatures and sea‐ice conditions can offer insight into how anthropogenic climate change may impact Arctic areas such as the Alaskan North Slope in the future. We contribute
Briana A. Edgerton, Melissa L. Chipman
wiley   +1 more source

Brain metastases exhibit distinct spatial patterns of resident and infiltrating macrophages. [PDF]

open access: yesCell Death Discov
Ratzabi A   +7 more
europepmc   +1 more source

The Early Upper Palaeolithic open‐air site of Friedrichsdorf‐Seulberg, Germany, in the context of the northern central European Aurignacian

open access: yesBoreas, EarlyView.
Our knowledge of the Early Upper Palaeolithic occupation in northern central Europe is very limited, and recent research at the open‐air site of Friedrichsdorf‐Seulberg in Hesse, Germany, provides important new information on the Aurignacian. The site is rather small (26.5 m2) and spatial analysis identified a central hearth with two associated ...
Tilman Böckenförde   +5 more
wiley   +1 more source

Targeting protein–protein interactions with reversible covalent modalities: Non‐cysteine chemistries

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Protein–protein interactions (PPIs) are central to diverse cellular functions, and represent a rapidly expanding class of therapeutic targets. Advancements in covalent drug design have enabled small‐molecule drugs to overcome challenges associated with engaging these targets, such as limited durations of action and difficult‐to‐drug (expansive,
Ruchira Basu, Steven Fletcher
wiley   +1 more source

Refining the treatment of immune checkpoint inhibitor–associated myocarditis: Challenges, innovations and rechallenge considerations

open access: yesBritish Journal of Pharmacology, EarlyView.
Immune checkpoint inhibitor (ICI)‐associated myocarditis has emerged as a severe and clinically complex immune‐related toxicity that poses significant challenges for therapeutic decision‐making in routine cardio‐oncological care. High‐dose corticosteroids remain the first‐line therapy, yet their timing, dosage and tapering require careful clinical ...
Raluca I. Mincu   +10 more
wiley   +1 more source

Cerebral small vessel disease lesion segmentation methods: A systematic review. [PDF]

open access: yesCereb Circ Cogn Behav
Phelps J   +9 more
europepmc   +1 more source

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