Results 71 to 80 of about 2,560 (288)

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

Solar-like Oscillations in Accreting Pre-main-sequence Stars: Insights and Prospects

The Astrophysical Journal
We present theoretical predictions for solar-like oscillators in the pre-main-sequence (pre-MS) phase of stellar evolution. Our pre-MS models start from a stellar seed of 0.01 solar masses that gains mass through accretion, offering an alternative ...
Johannes Jørgensen, Konstanze Zwintz, Ebraheem Farag, Eduard I. Vorobyov, Thomas Steindl   +4 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

The Population of Massive Stars in Active Galactic Nuclei Disks

The Astrophysical Journal
Gravitational instability in the outskirts of active galactic nuclei (AGN) disks leads to disk fragmentation and formation of ∼300 M _⊙ supermassive stars with potentially long lifetimes.
Yi-Xian Chen, Douglas N. C. Lin
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Pulse Profiles of Accreting Neutron Stars from GRMHD Simulations

The Astrophysical Journal
The pulsed X-ray emission from the neutron star surface acts as a window to study the state of matter in the neutron star interior. For accreting millisecond pulsars, the surface X-ray emission is generated from the “hotspots” formed due to the ...
Pushpita Das, Tuomo Salmi, Jordy Davelaar, Oliver Porth, Anna Watts   +4 more
doaj   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

2D MODELLING OF THE GAS FLOW STRUCTURE IN THE SYMBIOTIC STAR Z ANDROMEDAE

Odessa Astronomical Publications, 2017
The 2D gasdynamical simulations of gas structure in the symbiotic star Z And have been carried out for different stellar wind regimes. Since the mechanisms of gas acceleration in stellar atmospheres are not well studied, the parametric representation of ...
E. Yu. Kilpio
doaj   +1 more source

Group accretion in Milky Way-like stellar haloes

Astronomy & Astrophysics
As galaxies form hierarchically, larger satellites can accrete alongside smaller companions in group infall events. This coordinated accretion is likely to have left signatures in the Milky Way's stellar halo that we can see today. Our goal is to characterise the possible groups of companions that accompanied larger known accretion events of our Galaxy,
Callingham, Thomas M., Helmi, Amina
openaire   +3 more sources