Results 91 to 100 of about 91,576 (294)
FEBS Letters, EarlyView.Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas +3 more
wiley +1 more source
Bondi-like Accretion Flow Dynamics: The Role of Gravitational Potential
The Astrophysical JournalThe formation of massive black holes and their coevolution with host galaxies are pivotal areas of modern astrophysics. Spherical accretion onto a central point mass serves as a foundational framework in cosmological simulations, semi-analytical models ...
Razieh Ranjbar +2 more
doaj +1 more source
Accretion flares from stellar collisions in galactic nuclei
Astronomy & AstrophysicsContext. The strong tidal force in a supermassive black hole’s (SMBH) vicinity, coupled with a higher stellar density at the center of a galaxy, make it an ideal location to study the interaction between stars and black holes. Two stars moving near the SMBH could collide at a very high speed, which can result in a high energy flare.
B. X. Hu, A. Loeb
openaire +2 more sources
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
The Growth of Galaxy Stellar Haloes over 0.2 ≤ z ≤ 1.1
The Astrophysical JournalGalaxies are predicted to assemble their stellar haloes through the accretion of stellar material from interactions with their cosmic environment. Observations that trace stellar halo buildup probe the processes that drive galaxy size and stellar mass ...
Devin J. Williams +11 more
doaj +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Solar-like Oscillations in Accreting Pre-main-sequence Stars: Insights and Prospects
The Astrophysical JournalWe present theoretical predictions for solar-like oscillators in the pre-main-sequence (pre-MS) phase of stellar evolution. Our pre-MS models start from a stellar seed of 0.01 solar masses that gains mass through accretion, offering an alternative ...
Johannes Jørgensen +4 more
doaj +1 more source
Accretion signatures in the X-shooter spectrum of the substellar companion to SR12
, 2017 About a dozen substellar companions orbiting young stellar objects or pre-main sequence stars at several hundred au have been identified in the last decade.
Bayo, Amelia +7 more
core +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
, 2015 Observational studies of halo stars during the last two decades have placed some limits on the quantity and nature of accreted dwarf galaxy contributions to the Milky Way stellar halo by typically utilizing stellar phase-space information to identify the
Jessop, Will +3 more
core +1 more source