Results 101 to 110 of about 91,576 (294)

Group accretion in Milky Way-like stellar haloes

Astronomy & Astrophysics
As galaxies form hierarchically, larger satellites can accrete alongside smaller companions in group infall events. This coordinated accretion is likely to have left signatures in the Milky Way's stellar halo that we can see today. Our goal is to characterise the possible groups of companions that accompanied larger known accretion events of our Galaxy,
Callingham, Thomas M., Helmi, Amina
openaire   +3 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Pulse Profiles of Accreting Neutron Stars from GRMHD Simulations

The Astrophysical Journal
The pulsed X-ray emission from the neutron star surface acts as a window to study the state of matter in the neutron star interior. For accreting millisecond pulsars, the surface X-ray emission is generated from the “hotspots” formed due to the ...
Pushpita Das, Tuomo Salmi, Jordy Davelaar, Oliver Porth, Anna Watts   +4 more
doaj   +1 more source

POISSON project - II - A multi-wavelength spectroscopic and photometric survey of young protostars in L 1641

, 2011
Characterising stellar and circumstellar properties of embedded young stellar objects (YSOs) is mandatory for understanding the early stages of the stellar evolution.
A. Caratti o Garatti, Adams, Adams, Alecian, Alexander, Allen, Andre, Antona, Antoniucci, Antoniucci, B. Nisini, Baldovin-Saavedra, Baraffe, Beck, Bergin, Boogert, Buzzoni, Calvet, Caratti o Garatti, Caratti o Garatti, Caratti o Garatti, Cardelli, Carr, Chen, Chen, Chiar, Cieza, Cieza, Connelley, Connelley, Covey, Cushing, D. Lorenzetti, Davies, Davis, Davis, Dent, Di Francesco, Doppmann, Edwards, Enoch, Esteban, Esteban, Evans, Fang, Fazio, Fedele, Fischer, Forbrich, Garcia Lopez, Garcia Lopez, Garcia Lopez, Gerakines, Gorlova, Greene, Gullbring, Hamann, Hamann, Hartigan, Hartmann, Hartmann, Herczeg, Hernández, Hillenbrand, Houck, J. Eislöffel, Kelly, Kenyon, Kenyon, Kleinmann, Kóspál, Lada, Lahuis, Lahuis, Luhman, Makovoz, Manoj, Megeath, Merín, Meyer, Moorwood, Morales-Calderón, Morgan, Muzerolle, Muzerolle, Muzerolle, Natta, Natta, Nisini, Nisini, Nisini, Nussbaumer, Peterson, Podio, Prato, R. Garcia Lopez, Rayner, Reipurth, Rieke, Rieke, Rigliaco, Robitaille, Rossi, Rowles, S. Antoniucci, S. Cabrit, Shu, Sicilia-Aguilar, Sicilia-Aguilar, Siess, Skrutskie, Spezzi, Strom, T. Giannini, T. P. Ray, Takami, Terebey, Watson, White, Whitney, Whitney, Williams, York, Zacharias   +123 more
core   +3 more sources

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

The Population of Massive Stars in Active Galactic Nuclei Disks

The Astrophysical Journal
Gravitational instability in the outskirts of active galactic nuclei (AGN) disks leads to disk fragmentation and formation of ∼300 M _⊙ supermassive stars with potentially long lifetimes.
Yi-Xian Chen, Douglas N. C. Lin
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Orbital decomposition of the nuclear regions in the early-type galaxy FCC 47: Unveiling the nuclear cluster origin

Astronomy & Astrophysics
Context. Nuclear star clusters (NSCs) are among the densest stellar systems in the Universe and often coexist with supermassive black holes (SMBHs) at galaxy centres.
Lamprecht J., Feldmeier-Krause A., Lyubenova M., Fahrion K., Thater S., Jethwa P., Reiter S., Falcón-Barroso J., Maindl T. I., Santucci G., Breda I.   +10 more
doaj   +1 more source

Collapse of a molecular cloud core to stellar densities: the radiative impact of stellar core formation on the circumstellar disc

, 2010
We present results from the first three-dimensional radiation hydrodynamical calculations to follow the collapse of a molecular cloud core beyond the formation of the stellar core.
Alexander, Armitage, Baraffe, Bate, Bate, Bate, Benz, Benz, Boley, Boss, Cha, Durisen, Grossman, Hartmann, Kenyon, Larson, Machida, Machida, Machida, Masunaga, Matthew R. Bate, Morris, Norman, Pollack, Price, Price, Price, Price, Saigo, Saigo, Scott, Stamatellos, Tomida, Tscharnuter, Tscharnuter, Vorobyov, Vorobyov, Whitehouse, Whitehouse, Zhu   +39 more
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source