Results 111 to 120 of about 91,576 (294)

A New Parameter In Accretion Disk Model

, 2000
Taking optically thin accretion flows as an example, we investigate the dynamics and the emergent spectra of accretion flows with different outer boundary conditions (OBCs) and find that OBC plays an important role in accretion disk model.
AF Illarionov, E Quataert, F Yuan, F Yuan, IV Igumenshchev, JF Lu, LS Sparke, MA Abramowicz, MA Abramowicz, NI Shakura, R Coker, R Matsumoto, R Narayan, R Narayan, R Narayan, X Chen, X Chen   +16 more
core   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Gaia23bab: A New EXor

The Astrophysical Journal
On 2023 March 6, the Gaia telescope alerted a 2 mag burst from Gaia23bab, a young stellar object in the Galactic plane. We observed Gaia23bab with the Large Binocular Telescope obtaining optical and near-infrared spectra close in time to the peak of the ...
T. Giannini, E. Schisano, B. Nisini, P. Ábrahám, S. Antoniucci, K. Biazzo, F. Cruz-Sáenz de Miera, E. Fiorellino, M. Gangi, A. Kóspál, M. Kuhn, E. Marini, Z. Nagy, D. Paris   +13 more
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Circumstellar Disk Accretion Across the Lagoon Nebula: The Influence of Environment and Stellar Mass

The Astronomical Journal
Pre-main-sequence disk accretion is pivotal for determining the final stellar properties and the early conditions for close-in planets. We aim to establish the impact of internal (stellar mass) and external (radiation field) parameters on the disk ...
Laura Venuti, Ann Marie Cody, Giacomo Beccari, Luisa M. Rebull, Michael J. Irwin, Apoorva Thanvantri, Sowmya Thanvantri, Silvia H. P. Alencar, Clara O. Leal, Geert Barentsen, Janet E. Drew, Steve B. Howell   +11 more
doaj   +1 more source

The High Energy X-ray Probe (HEX-P): probing accretion onto stellar mass black holes

Frontiers in Astronomy and Space Sciences
Accretion is a universal astrophysical process that plays a key role in cosmic history, from the epoch of reionization to galaxy and stellar formation and evolution. Accreting stellar-mass black holes in X-ray binaries are one of the best laboratories to
Riley M. T. Connors, John A. Tomsick, Paul Draghis, Benjamin Coughenour, Aarran W. Shaw, Javier A. García, Javier A. García, Dominic Walton, Kristin Madsen, Daniel Stern, Nicole Cavero Rodriguez, Thomas Dauser, Melania Del Santo, Jiachen Jiang, Henric Krawczynski, Honghui Liu, Joseph Neilsen, Michael Nowak, Sean Pike, Andrea Santangelo, Navin Sridhar, Navin Sridhar, Navin Sridhar, Andrew West, Jörn Wilms   +24 more
doaj   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Wind-fed Supermassive Black Hole Accretion in the Ultracompact Dwarf Galaxy M60-UCD1

The Astrophysical Journal
Ultracompact dwarf galaxies (UCDs) are thought to be remnants of stripped galactic nuclei, among which a handful are known to host a central supermassive black hole (SMBH).
Zhao Su, Zhiyuan Li, Meicun Hou
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Competitive Accretion in Clusters and the IMF

, 2000
Observations have revealed that most stars are born in clusters. As these clusters typically contain more mass in gas than in stars, accretion can play an important role in determining the final stellar masses.
Bonnell, Ian A.
core   +1 more source