Results 131 to 140 of about 91,576 (294)

Stellar winds and accretion in HMXBs

, 2017
High Mass X-ray Binaries are excellent laboratories where current models of stellar winds and accretion physics can be tested. In this talk we will present XMM-Newton and Chandra observations of several HMXBs in order to explore the structure of the stellar wind of their massive star donors and its interplay with the accretion onto the neutron star. In
Torrejon, Jose M., Sanjurjo-Ferrín, Graciela, Postnov, Konstantin, Oskinova, Lidia M., Rodes Roca, José Joaquín, Bernabeu, Guillermo   +5 more
openaire   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Constraining Wind-driven Accretion onto Gaia BH3 with Chandra

The Astrophysical Journal
Gaia BH3 is the most massive known stellar-origin black hole in the Milky Way, with a mass M _• ≈ 33 M _⊙ . Detected from Gaia’s astrometry, this black hole is in the mass range of those observed via gravitational waves, whose nature is still highly ...
Nico Cappelluti, Fabio Pacucci, Günther Hasinger   +2 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Tests of Disk-locking in T Tauri Stars of the Orion Nebula Cluster

The Astrophysical Journal
We look for specific correlations predicted by magnetospheric accretion models for young stars that assume disk-locking using stellar and accretion parameters derived from low-resolution HST-STIS spectra of 33 T Tauri stars in the Orion Nebula Cluster ...
Margaret A. Mueller, Christopher M. Johns-Krull, Keivan G. Stassun, Don M. Dixon   +3 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Radiation Hydrodynamic Simulations of Massive Stars in Gas-rich Environments: Accretion of AGN Stars Suppressed by Thermal Feedback

The Astrophysical Journal
Massive stars may form in or be captured into active galactic nuclei (AGN) disks. Recent 1D studies employing stellar-evolution codes have demonstrated the potential for rapid growth of such stars through accretion up to a few hundred solar masses.
Yi-Xian Chen, Yan-Fei Jiang, Jeremy Goodman, Douglas N. C. Lin   +3 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Accretion onto the Embedded Protostar L1527 IRS: Insights from JWST NIRSpec and MIRI Observations

The Astrophysical Journal
Accretion is the primary driver of protostellar evolution, regulating mass assembly and shaping the physical and chemical environments of young stellar objects.
W. Blake Drechsler, John J. Tobin, Patrick D. Sheehan, Leslie W. Looney, S. Thomas Megeath, Ewine F. Van Dishoeck, Valentin J. M. Le Gouellec, Thomas P. Greene, Logan Francis, R. Devaraj, Martijn van Gelder, Lee Hartmann, Lukasz Tychoniec, Nuria Calvet, William J. Fischer   +14 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source