Results 121 to 130 of about 91,576 (294)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Planet Formation Regulated by Galactic-scale Interstellar Turbulence

The Astrophysical Journal Letters
Planet formation occurs over a few Myr within protoplanetary disks of dust and gas, which are often assumed to evolve in isolation. However, extended gaseous structures have been uncovered around many protoplanetary disks, suggestive of late-stage infall
Andrew J. Winter, Myriam Benisty, Sean M. Andrews   +2 more
doaj   +1 more source

Accretion in stellar clusters and the IMF

, 2001
We present a simple physical mechanism that can account for the observed stellar mass spectrum for masses $\ms \simgreat 0.5 \solm$. The model depends solely on the competitive accretion that occurs in stellar clusters where each star's accretion rate depends on the local gas density and the square of the accretion radius.
Bonnell, I. A., Clarke, C. J., Bate, M. R., Pringle, J. E.   +3 more
openaire   +2 more sources

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Rotational Evolution of Classical T Tauri Stars: Models and Observations

The Astrophysical Journal
We developed a grid of stellar rotation models for low-mass and solar-type classical T Tauri stars (CTTS; 0.3 M _⊙ < M _* < 1.2 M _⊙ ). These models incorporate the star–disk interaction and magnetospheric ejections to investigate the evolution of the ...
Javier Serna, Giovanni Pinzón, Jesús Hernández, Ezequiel Manzo-Martínez, Karina Mauco, Carlos G. Román-Zúñiga, Nuria Calvet, Cesar Briceño, Ricardo López-Valdivia, Marina Kounkel, Guy S. Stringfellow, Keivan G. Stassun, Marc Pinsonneault, Lucia Adame, Lyra Cao, Kevin Covey, Amelia Bayo, Alexandre Roman-Lopes, Christian Nitschelm, Richard R. Lane   +19 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

The magnetospheric accretion/ejection process in young stellar objects: open issues and perspectives

EPJ Web of Conferences, 2014
This summary talk aims at highlighting some of the remaining open issues regarding the physics of the magnetospheric accretion/ejection process in young stellar objects (YSOs).
Bouvier J.
doaj   +1 more source

Neutron star accretion in a stellar envelope

The Astrophysical Journal, 1993
Steady spherically symmetric accretion onto a neutron star is possible for a mass accretion rate ˙M≥10 −3 M ○. yr −1 ; the gravitational energy is lost to neutrinos. In the scenario of neutron star spiral-in through a massive stellar envelope, the neutron star accretion rate derived from the Bondi-Hoyle theory is ≥0.2 M ○. yr −1 . Radiation pressure
openaire   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Stellar streams around dwarf galaxies in the local Universe

Astronomy & Astrophysics
Context. While mergers between massive galaxies and their dwarf satellites have been well studied, the properties of dwarf–dwarf satellite mergers are not well constrained.
Sakowska Joanna D., Martínez-Delgado David, Pearson Sarah, Riquel-Castilla Francisco J., Starkenburg Tjitske K., Donatiello Giuseppe, Deason Alis, Erkal Denis, Taylor Ethan D.   +8 more
doaj   +1 more source