Results 141 to 150 of about 801 (259)

Phosphorylation‐Facilitated CKB Lactylation At K11 By GCN5 Enhances Creatine Kinase Activity and Mitigates Neuronal Damage After Cerebral Ischemia‐Reperfusion

Advanced Science, EarlyView.
This study uncovers hierarchical coordination between K11 lactylation and S199 phosphorylation of CKB in cerebral ischemia‐reperfusion injury. Such dual modifications potentiate CKB enzymatic function, remodel energy metabolism, alleviate oxidative stress and neuronal damage, and represent a viable therapeutic target for stroke treatment.
Chao Duan, Ruolin Zhang, Shihui Ding, Ying Feng, Tao Shen, Ziwei Wang, Wendai Bao, Ke Shui, Jun Qin, Jun Chen, Min Zhang, Zijing Ren, Dongmei Zhao, Xingrong Guo, Zhibing Ai, Xin Yang, Peiyang Zhou, Zhiqiang Dong   +17 more
wiley   +1 more source

Magnetogravitationally regulated streamer accretion onto a class 0 protostellar system. [PDF]

Sci Adv
Huang B, Girart JM, Stephens IW, Megeath T, Le Gouellec VJM, Murillo NM, Cortés P, Fernández-López M, Li ZY, Looney LW, López-Vázquez JA, Pineda JE, Sánchez-Monge Á, Sanhueza P, Sadavoy S, Zhang Q, Hull CLH, Karnath N, Liang E, Myers PC.   +19 more
europepmc   +1 more source

A Review on Catalytic Nanostructured Electrodes for Wearable and Implantable Abiotic Glucose Fuel Cells

Advanced Science, EarlyView.
This review identifies current and future directions in abiotic nanostructured catalysts to develop reliable and sustainable glucose fuel cells to power the next generation of bioelectronic devices. ABSTRACT The global rise in incidence of chronic diseases has led to the demand for innovative solutions that help patients manage their conditions with ...
Asghar Niyazi, Hannah S. Leese, Benjamin Metcalfe, Mirella Di Lorenzo   +3 more
wiley   +1 more source

Origin of compact exoplanetary systems during disk infall. [PDF]

Nat Commun
Rufu R, Canup RM.
europepmc   +1 more source

Redox‐Dependent Chaperoning of GBF1 Condensates Regulates Seed Germination in Arabidopsis

Advanced Science, EarlyView.
In dormant seeds (low ROS), GBF1 forms liquid condensates to repress the germination gene CathB3, and the chaperone GIP1 maintains condensate liquidity and repressive activity. Upon imbibition (high ROS), ROS oxidize GIP1 during germination, impairing its chaperone function.
Yunying Wang, Xiaofeng Fang
wiley   +1 more source

Origin and Evolution of the Galilean Satellites Within the Jovian System. [PDF]

Space Sci Rev
Nimmo F, Canup R, Fujii Y, Izidoro A, Ji J, McKinnon W, Mousis O, Ormel C, Ogihara M, Stevenson D, Blanc M.   +10 more
europepmc   +1 more source

Water in the terrestrial planet-forming zone of the PDS 70 disk. [PDF]

Nature, 2023
Perotti G, Christiaens V, Henning T, Tabone B, Waters LBFM, Kamp I, Olofsson G, Grant SL, Gasman D, Bouwman J, Samland M, Franceschi R, van Dishoeck EF, Schwarz K, Güdel M, Lagage PO, Ray TP, Vandenbussche B, Abergel A, Absil O, Arabhavi AM, Argyriou I, Barrado D, Boccaletti A, Caratti O Garatti A, Geers V, Glauser AM, Justannont K, Lahuis F, Mueller M, Nehmé C, Pantin E, Scheithauer S, Waelkens C, Guadarrama R, Jang H, Kanwar J, Morales-Calderón M, Pawellek N, Rodgers-Lee D, Schreiber J, Colina L, Greve TR, Östlin G, Wright G.   +44 more
europepmc   +1 more source

HNRNPD Induces Radioresistance in Nasopharyngeal Carcinoma by Sequestering GRAMD4 mRNA in Stress Granules

Advanced Science, EarlyView.
HNRNPD promotes radioresistance in nasopharyngeal carcinoma by enhancing stress granule assembly and sequestering GRAMD4 mRNA. This suppresses GRAMD4 translation and inhibits mitochondrial apoptosis. Targeting the integrated stress response with ISRIB restores GRAMD4 expression and sensitizes tumors to radiotherapy, revealing a translational control ...
Yingzi Li, Tong Xiang, Yuanyuan Liu, Desheng Weng, Jingjing Zhao, Hao Chen, Yan Tang, Songzuo Xie, Hao Zhang, Jun Luo, Xinyi Yang, Qiuzhong Pan, Muping Di, Jianchuan Xia   +13 more
wiley   +1 more source

Simulations of multi-phase gas in and around galaxies. [PDF]

Living Rev Comput Astrophys
Gronke M, E Schneider E.
europepmc   +1 more source

Stress History Establishes a Transient Tolerant State That Shapes Antibiotic Survival Upon Resuscitation

Advanced Science, EarlyView.
High‐throughput single‐cell analysis of resuscitating bacteria reveals a starvation‐history‐dependent transiently tolerant subpopulation that survives β$\beta$‐lactam exposure by temporarily reducing growth. Distinct from classical persisters, these actively growing yet dynamically modulated cells dominate survival across clinically relevant antibiotic
Kieran Abbott, Georgeos Hardo, Ruizhe Li, Jack Bradley, Ashraf Zarkan, Somenath Bakshi   +5 more
wiley   +1 more source