Results 171 to 180 of about 801 (259)

A direct black-hole mass measurement in a little red dot at high redshift. [PDF]

Nature
Juodžbalis I, Marconcini C, D'Eugenio F, Maiolino R, Marconi A, Übler H, Scholtz J, Ji X, Jones GC, Perna M, Arribas S, Bennett JS, Bromm V, Bunker AJ, Carniani S, Charlot S, Cresci G, Dayal P, Egami E, Fabian A, Inayoshi K, Isobe Y, Ivey LR, Koudmani S, Laporte N, Liu B, Lyu J, Mazzolari G, Monty S, Parlanti E, Pérez-González PG, Robertson B, Schneider R, Sijacki D, Tacchella S, Trinca A, Valiante R, Volonteri M, Witstok J, Zhang S.   +39 more
europepmc   +1 more source

Fine‐Tuned Regulation of mRNA Translation and Transport by STAU2 Condensate Facilitates Neuronal Development and Plasticity

Advanced Science, EarlyView.
STAU2 undergoes phase separation to form dynamic condensates that package target mRNAs and deliver them to the distal ends of growing neuronal dendrites. STAU2 condensates stabilize embedded mRNAs and repress their translation. Synaptic activity bidirectionally remodels STAU2 condensates, coordinating local translation of STAU2‐associated mRNAs ...
Shijing Huang, Yuanyuan Chu, Ruiqian Zhao, Siyu Li, Yu Feng, Hongdan Zheng, Yunli Xie, Tong Wang, Wenyu Wen   +8 more
wiley   +1 more source

Formation of free-floating planetary mass objects via circumstellar disk encounters. [PDF]

Sci Adv
Fu Z, Deng H, Lin DNC, Mayer L.
europepmc   +1 more source

In Situ Stress‐Dispersing Hydrogel Millispheres via Load Redistribution to Restore Nucleus Pulposus Metabolic Homeostasis

Advanced Science, EarlyView.
Local stress concentration disrupts metabolic homeostasis and induces inflammation in the nucleus pulposus (NP), thereby accelerating intervertebral disc degeneration (IDD). A biomimetic HA/ChS hydrogel millimeter sphere (ChS@HM) is developed to enable synergistic stress dispersion and sustained hydration lubrication.
Ang Li, Hui Yuan, Honglei Xiao, Xiaodong Liu, Wenguo Cui   +4 more
wiley   +1 more source

A precise metallicity and carbon-to-oxygen ratio for a warm giant exoplanet from its panchromatic JWST emission spectrum. [PDF]

Proc Natl Acad Sci U S A
Wiser LS, Bell TJ, Line MR, Schlawin E, Beatty TG, Welbanks L, Greene TP, Parmentier V, Murphy MM, Fortney JJ, Arnold K, Mehta N, Ohno K, Mukherjee S.   +13 more
europepmc   +1 more source

Aptamer‐Directed Porous DNA Nanocomposite Hydrogel for Active Pulp Preservation: Immunomodulation, Stem Cell Recruitment and Reparative Dentinogenesis

Advanced Science, EarlyView.
This study presents an injectable DNA‐based porous hydrogel integrating catechol motifs and targeting aptamers for pulpitis management. Upon in situ crosslinking, the scaffold actively recruits endogenous dental pulp stem cells, restores redox homeostasis, and modulates immune responses.
Luhui Cai, Huan Yu, Zihan Ni, Kan Chen, I‐Chen Tsai, Zeyu Bao, Shuo Sun, Weichang Li, Yunhua Chen, Qiong Xu   +9 more
wiley   +1 more source

Information-Entropy Analysis of Stellar Evolutionary Stages with Application to FS CMa Objects. [PDF]

Entropy (Basel)
Zhanabaev Z, Akniyazova A, Ashimov Y.
europepmc   +1 more source

Synergistic Dual Slip‐Link Toughening of a Water‐Rich Double Network Hydrogel Combining Slide‐Ring and Highly Entangled Networks

Advanced Science, EarlyView.
Two distinct slip‐link mechanisms – the slide‐ring pulley effect and highly entangled chains – are combined in a water‐rich double network hydrogel, achieving synergistic toughening, near‐complete reversibility, and exceptional friction tear resistance at >$>$91 wt.% water.
Subhankar Mandal, Saleh Assadi, Aseem Milind Visal, Ignacio Lorente Montero, Franck J. Vernerey, Carson J. Bruns   +5 more
wiley   +1 more source

Direct evidence for magnetohydrodynamic disk winds driving rotating outflows in protostar HOPS 358. [PDF]

Nat Commun
Kim CH, Lee JE, Johnstone D, Herczeg GJ, Lee CF, Francis L, Sheehan PD.   +6 more
europepmc   +1 more source

Drug‐Induced Cuproptosis Defines the Therapeutic Window of Celecoxib in Intervertebral Disc Degeneration via the HSP90‐RBX1 Axis

Advanced Science, EarlyView.
This study reveals the dual role of celecoxib in intervertebral disc degeneration. While low concentrations are protective, high concentrations induce toxicity by upregulating HSP90, which synergizes with USP15 to deubiquitinate and stabilize RBX1. This leads to degradation of COMMD1/ATP7B, copper dyshomeostasis, and ultimately, cuproptosis.
Youfeng Guo, Hongju Xiao, Shenghao Ba, Yu Zhou, Bijun Wang, Bin Yu, Yufeng Huang, Haihong Zhao, Zhefan Stephen Chen, Na Shen, Zhaoyu Ba, Desheng Wu   +11 more
wiley   +1 more source