Results 201 to 210 of about 35,614 (300)

A young progenitor for the most common planetary systems in the Galaxy. [PDF]

open access: yesNature
Livingston JH   +41 more
europepmc   +1 more source

Jupiter-like planets might be common in a low-density environment. [PDF]

open access: yesNat Commun, 2023
Gratton R   +8 more
europepmc   +1 more source

Gut Mycobiota‐Associated Tryptophan Catabolites Protect Against Metabolic Dysfunction‐Associated Steatotic Liver Disease

open access: yesAdvanced Science, EarlyView.
ABSTRACT Accumulating evidence suggests that the intestinal microbiota participates in the progression of metabolic dysfunction‐associated steatotic liver disease (MASLD) through microbiota‐host interaction. However, the beneficial role of commensal mycobiota in MASLD progression remains poorly understood.
Shuping Qiao   +11 more
wiley   +1 more source

Timing Mechanotransduction: Mechanically Dynamic Biomaterials Reveal the Temporal Hierarchy of YAP/TAZ Control Nodes

open access: yesAdvanced Science, EarlyView.
This work develops dynamically softening polyacrylamide hydrogels for time‐resolved imaging during continuous mechanical transitions. The study revealed that mechanotransduction is biphasic; YAP/TAZ inactivation is driven by early loss of the nucleocytoskeletal continuum connecting subnuclear adhesions, F‐actin, and the nuclear envelope, coupled with ...
Alessandro Gandin   +12 more
wiley   +1 more source

A precise metallicity and carbon-to-oxygen ratio for a warm giant exoplanet from its panchromatic JWST emission spectrum. [PDF]

open access: yesProc Natl Acad Sci U S A
Wiser LS   +13 more
europepmc   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

open access: yesAdvanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong   +5 more
wiley   +1 more source

Embedded CRISPRi Enhances Gene‐Silencing Efficiency in Drosophila

open access: yesAdvanced Science, EarlyView.
Current CRISPR interference (CRISPRi) technology in Drosophila has limited efficiency. This study introduces the emCRISPRi platform, which significantly enhances transcriptional silencing efficacy by embedding inhibitory domains within the dCas9 architecture.
Pengchong Fu   +7 more
wiley   +1 more source

Direct evidence for magnetohydrodynamic disk winds driving rotating outflows in protostar HOPS 358. [PDF]

open access: yesNat Commun
Kim CH   +6 more
europepmc   +1 more source

Home - About - Disclaimer - Privacy