Results 241 to 250 of about 35,527 (304)

Attenuated Bacteria‐Based Tumor Therapy: Clinical Application Risks, Marketing Approval Restrictions, and Coping Strategies

Advanced Science, EarlyView.
This review comprehensively overviews attenuated bacteria‐based tumor therapy, highlighting key methodologies and recent progress. It examines strategies for enhancing safety, stabilizing efficacy, optimizing manufacturing, and navigating regulatory pathways.
Yucheng Liu, Junhong Yao, Jiaxin Deng, Minjie Zhou, Kaiyue Shen, Shishuo Sun, Xiaoge Gao, Qing Zhang, Haiheng Xu   +8 more
wiley   +1 more source

Quasi-periodic X-ray eruptions years after a nearby tidal disruption event. [PDF]

Nature
Nicholl M, Pasham DR, Mummery A, Guolo M, Gendreau K, Dewangan GC, Ferrara EC, Remillard R, Bonnerot C, Chakraborty J, Hajela A, Dhillon VS, Gillan AF, Greenwood J, Huber ME, Janiuk A, Salvesen G, van Velzen S, Aamer A, Alexander KD, Angus CR, Arzoumanian Z, Auchettl K, Berger E, de Boer T, Cendes Y, Chambers KC, Chen TW, Chornock R, Fulton MD, Gao H, Gillanders JH, Gomez S, Gompertz BP, Fabian AC, Herman J, Ingram A, Kara E, Laskar T, Lawrence A, Lin CC, Lowe TB, Magnier EA, Margutti R, McGee SL, Minguez P, Moore T, Nathan E, Oates SR, Patra KC, Ramsden P, Ravi V, Ridley EJ, Sheng X, Smartt SJ, Smith KW, Srivastav S, Stein R, Stevance HF, Turner SGD, Wainscoat RJ, Weston J, Wevers T, Young DR.   +63 more
europepmc   +1 more source

Mechanisms of Aristolochic Acid Resistance in Specialist Butterflies and Evolutionary Insights for Potential Protective Pathways

Advanced Science, EarlyView.
The study provides an extreme example of insect adaptation to highly toxic defenses of host plants, and investigates the complex strategies to resist carcinogenic aristolochic acids, including physical isolation, metabolic detoxification, and DNA repair.
Yang Luan, Yubo Zhang, Jingjing Li, Jianqing Zhu, Yuyang Lei, Yushi Hu, Zhenqiang Xin, Tianpei Xie, Jiang Zheng, Yuanyuan Lin, Jingjing Shen, Yiyi Cao, Xinyue You, Jing Xi, Jiaying Wu, Weiying Liu, Xinyu Zhang, Yuanting Zheng, David J. Lohman, Leming Shi, Wei Zhang   +20 more
wiley   +1 more source

Water Versus Land on Temperate Rocky Planets. [PDF]

Space Sci Rev
Guimond CM, Spohn T, Berdyugina S, Byrne PK, Coltice N, Glaser DM, Lingam M, Lineweaver CH, Cawood PA.   +8 more
europepmc   +1 more source

Transforming Grain‐Boundary Brittle Precipitates to Ductility Pathways in Complex Concentrated Alloy

Advanced Science, EarlyView.
By engineering graded BCC/L12 interfaces, brittle precipitates in a complex concentrated alloy enable sequential deformation, realizing gigapascal strength with >20% elongation to solve the strength‐ductility trade‐off. ABSTRACT Conventional wisdom holds that hard grain‐boundary (GB) precipitates embrittle structural alloys by acting as crack ...
Zhixin Li, Xiao‐Tong Li, Zhaoqi Chen, Yushan Geng, Hao Gong, Sijia Hu, Wenli Song, Wanshun Xia, Chuanzheng Li, Linfa Peng, Yue Fan, Pengfei Guan, Bo Zhang, Weihua Wang, Yong Yang   +14 more
wiley   +1 more source

A radius valley between migrated steam worlds and evaporated rocky cores. [PDF]

Nat Astron
Burn R, Mordasini C, Mishra L, Haldemann J, Venturini J, Emsenhuber A, Henning T.   +6 more
europepmc   +1 more source

Deformable Eutectic Alloy With Near‐Theoretical Yield Strength via Hierarchical Nanoscale Multiphases and Sessile Defects

Advanced Science, EarlyView.
A CoCrFeNiTa0.4 eutectic high‐entropy alloy achieves a near‐theoretical yield strength of 2.6 GPa with 13.6% plasticity. This breakthrough stems from a hierarchical nanostructure (FCC‐Laves lamellae with L12/D022 precipitates), which alleviates the inter‐phase modulus/hardness mismatch through synergistic strengthening and toughening, guiding the ...
Yusha Luo, Qianqian Wang, Bo Sun, Ruixin Sheng, Zhijun Guo, Gaopeng Zou, Zhe Jia, Yang Tong, Gang Sha, Peter K. Liaw, Baolong Shen   +10 more
wiley   +1 more source

Challenges and opportunities for time-delay cosmography with multi-messenger gravitational lensing. [PDF]

Philos Trans A Math Phys Eng Sci
Birrer S, Smith GP, Shajib AJ, Ryczanowski D, Arendse N.   +4 more
europepmc   +1 more source

Hierarchical Strain‐Modified Medium‐Entropy Carbide Ceramics Exhibit Exceptional Ablation Resistance up to 2400°C

Advanced Science, EarlyView.
A novel strategy is developed by doping reduced graphene oxide (rGO) into a (HfZrTi)C medium‐entropy ceramic. This induces a hierarchical strain modification mechanism, synergistically inhibiting crack propagation at the microscale and dissipating stress at the mesoscale.
Junyi Xiao, Pengfei He, Lin Xue, Shujun Hu, Liliang Shao, Chuan Sun, Yunyun Ge, Jiangbo Cheng, Xiubing Liang   +8 more
wiley   +1 more source

Targeted Mitochondrial ECSIT Overexpression Attenuates MASH by Increasing OTUD3 Expression

Advanced Science, EarlyView.
Mitochondrial ECSIT expression is reduced during MASH pathogenesis. Overexpression of mitochondrial ECSIT mitigates steatohepatitis and maintains hepatic metabolic homeostasis. Mechanistically, ECSIT enhances intramitochondrial OTUD3 expression to stabilize SIRT3 through deubiquitination, thus preserving mitochondrial function and impeding disease ...
Yuqing Jiang, Tingting Tong, Pengxi Shi, Xiaofan Chen, Chenhao Wang, Qingyuan Weng, Sihan Chen, Linli Que, Qi Chen, Yuehua Li, Qiang Zhu, Jiantao Li   +11 more
wiley   +1 more source