Results 261 to 270 of about 8,281,459 (308)

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

High-temperature ²⁰⁵Tl decay clarifies ²⁰⁵Pb dating in early Solar System. [PDF]

Nature
Leckenby G, Sidhu RS, Chen RJ, Mancino R, Szányi B, Bai M, Battino U, Blaum K, Brandau C, Cristallo S, Dickel T, Dillmann I, Dmytriiev D, Faestermann T, Forstner O, Franczak B, Geissel H, Gernhäuser R, Glorius J, Griffin C, Gumberidze A, Haettner E, Hillenbrand PM, Karakas A, Kaur T, Korten W, Kozhuharov C, Kuzminchuk N, Langanke K, Litvinov S, Litvinov YA, Lugaro M, Martínez-Pinedo G, Menz E, Meyer B, Morgenroth T, Neff T, Nociforo C, Petridis N, Pignatari M, Popp U, Purushothaman S, Reifarth R, Sanjari S, Scheidenberger C, Spillmann U, Steck M, Stöhlker T, Tanaka YK, Trassinelli M, Trotsenko S, Varga L, Vescovi D, Wang M, Weick H, Yagüe Lopéz A, Yamaguchi T, Zhang Y, Zhao J.   +58 more
europepmc   +1 more source

Enhancing Oncological Care for India's Aging Population: Addressing the Complex Needs of Older Adults With Cancer

Aging and Cancer, EarlyView.
Aging‐associated physiological and molecular alterations pose significant challenges in cancer management among India's elderly. Limited geriatric oncology expertise, financial constraints, and inadequate specialized care exacerbate disparities. Strategic expansion of insurance coverage, integration of palliative care, and infrastructural advancements ...
Nihanthy D. Sreenath, Mathigatta Shivarudraiah S, Rajath Govind, Kaushik M R   +3 more
wiley   +1 more source

Helioseismic inference of the solar radiative opacity. [PDF]

Nat Commun
Buldgen G, Pain JC, Cossé P, Blancard C, Gilleron F, Pradhan AK, Fontes CJ, Colgan J, Noels A, Christensen-Dalsgaard J, Deal M, Ayukov SV, Baturin VA, Oreshina AV, Scuflaire R, Pinçon C, Lebreton Y, Corbard T, Eggenberger P, Salmon S, Hakel P, Kilcrease DP.   +21 more
europepmc   +1 more source

Predicting and Comparing the Subjective Health Experience of Older Cancer Survivors and Non‐Cancer Survivors: A Modeling Approach

Aging and Cancer, EarlyView.
This study underscores the significant influence of frailty and vitality on the subjective health experience of older cancer survivors with acceptance and control emerging as salient mediators. These findings affirm the conceptual and empirical robustness of the model highlighting its potential utility in shaping future interventions for older cancer ...
Damien S. E. Broekharst, Sjaak Bloem, Eline J. Mertens, Nathascha Hanzen, Michel van Agthoven   +4 more
wiley   +1 more source

An Abrupt Change in the Disk Fraction of Free-Floating Planets at the Deuterium-Burning Ignition Limit

Rodrigues T, Bouy H, Raymond S, Martín E, Bertin E, Romero JO, Barrado D, Huélamo N, Tamura M, Roig NM, Galli P, Cuillandre J.   +11 more
europepmc   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Reading Between the Lines: Determinants of a High-Quality Letter of Recommendation in Cardiothoracic Surgery. [PDF]

Ann Thorac Surg Short Rep
Go PH, Zulch ER, Zukowski M, Taylor MD, Reed MF.   +4 more
europepmc   +1 more source

Cosmic mysteries and the hydrogen 21-cm line: bridging the gap with lunar observations. [PDF]

Philos Trans A Math Phys Eng Sci
Fialkov A, Gessey-Jones T, Dhandha J.
europepmc   +1 more source

Strong Lensing by Galaxies. [PDF]

Space Sci Rev
Shajib AJ, Vernardos G, Collett TE, Motta V, Sluse D, Williams LLR, Saha P, Birrer S, Spiniello C, Treu T.   +9 more
europepmc   +1 more source