Results 131 to 140 of about 40,509 (299)

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

FEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source

Discovery of the Remarkably Red L/T Transition Object VHS J183135.58-551355.9

The Astronomical Journal
We present the discovery of VHS J183135.58−551355.9 (hereafter VHS J1831−5513), an L/T transition dwarf identified as a result of its unusually red near-infrared colors ( J − K _S = 3.633 ± 0.277 mag; J − W 2 = 6.249 ± 0.245 mag) from the VISTA ...
Thomas P. Bickle, Adam C. Schneider, Jonathan Gagné, Jacqueline K. Faherty, Austin Rothermich, Johanna M. Vos, Genaro Suárez, J. Davy Kirkpatrick, Aaron M. Meisner, Marc J. Kuchner, Adam J. Burgasser, Federico Marocco, Sarah L. Casewell, Dan Caselden, Daniella C. Bardalez Gagliuffi, The Backyard Worlds: Planet 9 Collaboration   +15 more
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Astrometric radial velocities. I. Non-spectroscopic methods for measuring stellar radial velocity

, 1999
High-accuracy astrometry permits the determination of not only stellar tangential motion, but also the component along the line-of-sight. Such non-spectroscopic (i.e.
Dravins, Dainis, Lindegren, Lennart, Madsen, Soren   +2 more
core  

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Lost Sisters Found: TESS and Gaia Reveal a Dissolving Pleiades Complex

The Astrophysical Journal
Most star clusters dissolve into the Galaxy over tens to hundreds of millions of years after they form. While recent Gaia studies have honed our view of cluster dispersal, the exact chronology of which star formation events begat which star cluster ...
Andrew W. Boyle, Luke G. Bouma, Andrew W. Mann   +2 more
doaj   +1 more source

Jupiter-like planets might be common in a low-density environment. [PDF]

Nat Commun, 2023
Gratton R, Mesa D, Bonavita M, Zurlo A, Marino S, Kervella P, Desidera S, D'Orazi V, Rigliaco E.   +8 more
europepmc   +1 more source