Results 221 to 230 of about 1,216,320 (294)

Associations between sedentary behavior and allostatic load: The 1970 British Cohort Study. [PDF]

Psychoneuroendocrinology
Chauntry AJ, Diana JC, Li Q, Seeman T, Courtney JB, Tyne WP, Whittaker AC, Turner AI, Teychenne M, Lassalle PP, Zieff G, Gibbs BB, Diaz KM, Puterman E, Lin FC, Kowalsky RJ, Stoner L, Hanson ED, Meyer ML.   +18 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Postmarketing analysis of sotatercept: identifying serious unlabelled events. [PDF]

Open Heart
Cao Z, Xiao Q, Li X, Zhang H, Zhang M.
europepmc   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Utilization of youth corners: a model for improving youth-friendly health services in Neno District, Southern Malawi. [PDF]

Glob Health Action
Kavuma T, Chibvunde S, Kabanda V, Munyaneza F, Mpinga K, Mphande I, Nhlema B, Banda C, Harare J, Ndarama E, Sandiyang'ane A, Aron MB.   +11 more
europepmc   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Generation and characterization of a Cre-inducible MAP3K1 gain-of-function model. [PDF]

Dis Model Mech
Xiao B, Mongan M, Ko CI, Hu YC, DeFalco T, Greis KD, Xia Y.   +6 more
europepmc   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Association of psychosocial stress with altered functional connectivity of large-scale brain networks in aging adults. [PDF]

Cogn Affect Behav Neurosci
Pfaff G, Paitel E, Soldan A, Albert M, Ryan L, Ugonna C, Chen NK, Huentelman M, Pettigrew C, Precision Aging®Network.   +9 more
europepmc   +1 more source