Results 251 to 260 of about 41,072 (339)

Characterizing Supernova Host Galaxies with FrankenBlast : A Scalable Tool for Transient Host Galaxy Association, Photometry, and Stellar Population Modeling

Anya E. Nugent, V. Ashley Villar, Alex Gagliano, David O. Jones, Asaf Horowicz, Kaylee de Soto, Bingjie Wang, Ben Margalit   +7 more
openalex   +1 more source

Cloning, expression, purification, and structural modeling of the Chandipura virus matrix protein. [PDF]

FEBS Open Bio
Grieben M.
europepmc   +1 more source

Stellar Associations in the Andromeda Nebula.

The Astrophysical Journal Supplement Series, 1964
openaire   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Widespread Progressive Telangiectasia in a 54-Year-Old Caucasian Male. [PDF]

Cureus
Kikina S, Ali L, Audet S, Koleva E, Imran A, Morley G, Alhameedi HN.   +6 more
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Semantic design of functional de novo genes from a genomic language model. [PDF]

Nature
Merchant AT, King SH, Nguyen E, Hie BL.
europepmc   +1 more source