Results 111 to 120 of about 931,455 (366)

Model atmospheres of chemically peculiar stars: Self-consistent empirical stratified model of HD24712

, 2009
High-resolution spectra of some chemically peculiar stars clearly demonstrate the presence of strong abundance gradients in their atmospheres. However, these inhomogeneities are usually ignored in the standard scheme of model atmosphere calculations ...
Alecian, Babel, Bard, Bard, Black, Blackwell, Blackwell, Blanco, Campos, D. Shulyak, Fleurier, Garz, Goncharsky, Hauck, Hauschildt, Hui-Bon-Hoa, Khan, Khan, Kochukhov, Kochukhov, Kochukhov, Kochukhov, Kochukhov, Kupka, L. Mashonkina, Lueftinger, Lundberg, Mashonkina, Mashonkina, Mashonkina, Mashonkina, Michaud, Nieuwenhuijzen, O. Kochukhov, Piskunov, Piskunov, Piskunov, Raassen, Ryabchikova, Ryabchikova, Ryabchikova, Ryabchikova, Rybicki, Rybicki, Seaton, Smith, Smith, Smith, Smith, Stepanov, T. Ryabchikova, Vogt, Warner, Weiss, Wolff   +54 more
core   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Additional JWST/NIRSpec Transits of the Rocky M Dwarf Exoplanet GJ 1132 b Reveal a Featureless Spectrum

The Astronomical Journal
As an archetypal M-dwarf rocky exoplanet, GJ 1132 b has a varied history of atmospheric measurements. At 1.13 R _⊕ , 1.66 M _⊕ , and 580 K, it orbits a bright, slowly rotating M dwarf in a 1.6 day period, making it a prime target for characterization. In
Katherine A. Bennett, Ryan J. MacDonald, Sarah Peacock, Junellie Perez, E. M. May, Sarah E. Moran, Lili Alderson, Jacob Lustig-Yaeger, Hannah R. Wakeford, David K. Sing, Kevin B. Stevenson, Natasha E. Batalha, Mercedes López-Morales, Munazza K. Alam, Joshua D. Lothringer, Guangwei Fu, James Kirk, Jeff A. Valenti, L. C. Mayorga, Kristin S. Sotzen   +19 more
doaj   +1 more source

Why one-dimensional models fail in the diagnosis of average spectra from inhomogeneous stellar atmospheres

, 2011
We investigate the feasibility of representing a structured multi-dimensional stellar atmosphere with a single one-dimensional average stratification for the purpose of spectral diagnosis of the atmosphere's average spectrum.
Abbett, Allende Prieto, Allende Prieto, Asplund, Asplund, Atroshchenko, Auer, Avrett, Ayres, Centeno, Fontenla, Han Uitenbroek, Holweger, Jacoutot, Kiselman, Koesterke, Nordlund, Nordlund, Rodriguez Hidalgo, Rybicki, Schaffenberger, Serena Criscuoli, Serenelli, Shchukina, Socas-Navarro, Socas-Navarro, Steffen, Stein, Stein, Trujillo Bueno, Uitenbroek, Uitenbroek, Uitenbroek   +32 more
core   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

An HST Transmission Spectrum of the Closest M Dwarf Transiting Rocky Planet LTT 1445Ab

The Astronomical Journal
Which rocky exoplanets have atmospheres? This presumably simple question is the first that must be answered to understand the prevalence of nearby habitable planets.
Katherine A. Bennett, David K. Sing, Kevin B. Stevenson, Hannah R. Wakeford, Zafar Rustamkulov, Natalie H. Allen, Joshua D. Lothringer, Ryan J. MacDonald, Nathan J. Mayne, Guangwei Fu   +9 more
doaj   +1 more source

Role of local absorption on the X-ray emission from MHD accretion shocks in classical T Tauri stars

EPJ Web of Conferences, 2014
Accretion processes onto classical T Tauri stars (CTTSs) are believed to generate shocks at the stellar surface due to the impact of supersonic downflowing plasma.
Bonito , Orlando , Argiroffi , Miceli , Reale , Peres , Matsakos , Stehle , Ibgui   +8 more
doaj   +1 more source

A Deep Chandra X-ray Spectrum of the Accreting Young Star TW Hydrae

, 2010
We present X-ray spectral analysis of the accreting young star TW Hydrae from a 489 ks observation using the Chandra High Energy Transmission Grating.
A. K. Dupree, Batalha, Brown, Calvet, Calvet, Chen, Costa, Cranmer, Cranmer, Drake, Drake, Dupree, Favata, Feldmeier, Fruscione, G. J. M. Luna, Gagné, Gregory, Hartmann, Hartmann, Herczeg, Herczeg, Huenemoerder, Huenemoerder, Kastner, Kastner, Lamzin, Mauche, Muzerolle, Muzerolle, N. S. Brickhouse, Ness, Orlando, Osten, Preibisch, Qi, Raymond, Romanova, S. R. Cranmer, S. Wolk, Sanz-Forcada, Smith, Smith, Testa   +43 more
core   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Stellar Models Also Limit Exoplanet Atmosphere Studies in Emission

The Astrophysical Journal
Stellar contamination has long been recognized as a major bottleneck in transmission spectroscopy, limiting our ability to accurately characterize exoplanet atmospheres—particularly for terrestrial worlds.
Thomas J. Fauchez, Elsa Ducrot, Benjamin V. Rackham, Kevin B. Stevenson, L. C. Mayorga, Julien de Wit   +5 more
doaj   +1 more source