Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
A Multispecies Atmospheric Escape Model with Excited Hydrogen and Helium: Application to HD209458b
The Astrophysical JournalAtmospheric escape shapes exoplanet evolution and star–planet interactions, with He I 10830 Å absorption serving as a key tracer of mass loss in hot gas giants.
Anna Ruth Taylor +6 more
doaj +1 more source
Effect of convective outer layers modeling on non-adiabatic seismic observables of delta Scuti stars
, 2007 The identification of pulsation modes in delta Scuti stars is mandatory to constrain the theoretical stellar models. The non-adiabatic observables used in the photometric identification methods depend, however,on convection modeling in the external ...
Alexander +43 more
core +3 more sources
Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, EarlyView.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source
3D-simulation of the Outer Convection-zone of an A-star
, 2004 The convection code of Nordlund & Stein has been used to evaluate the 3D, radiation-coupled convection in a stellar atmosphere with Teff=7300K, logg=4.3 and [Fe/H]=0.0, corresponding to a main-sequence A9-star.
Trampedach, Regner
core +2 more sources
Round Table Summary: Stellar interferometry as a tool to investigate\n atmospheres and to compare observations with models [PDF]
, 2003 M. Wittkowski
openalex +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Magnetic pressure support and accretion disk spectra
, 2006 Stellar atmosphere models of ionized accretion disks have generally neglected the contribution of magnetic fields to the vertical hydrostatic support, although magnetic fields are widely believed to play a critical role in the transport of angular ...
Blaes, O +9 more
core +1 more source
Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics
FEBS Open Bio, EarlyView.Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini +2 more
wiley +1 more source
Constraints on Quaoar’s Rings and Atmosphere from JWST/NIRCam Observations of a Stellar Occultation
The Planetary Science JournalObservations of stellar occultations have revealed that small bodies are capable of hosting ring systems. The trans-Neptunian object Quaoar is the host of an enigmatic ring system, with two rings located well outside the Roche limit. To better understand
Benjamin Proudfoot +5 more
doaj +1 more source