Results 161 to 170 of about 2,514,308 (344)

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

ORACLE: A Real-time, Hierarchical, Deep Learning Photometric Classifier for the LSST

The Astrophysical Journal
We present the Online Ranked Astrophysical CLass Estimator (ORACLE), the first hierarchical deep-learning model for real-time, context-aware classification of transient and variable astrophysical phenomena. ORACLE is a recurrent neural network with gated
Ved G. Shah, Alex Gagliano, Konstantin Malanchev, Gautham Narayan, Alex I. Malz, and the LSST Dark Energy Science Collaboration   +5 more
doaj   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Predictions for the Detectability of Milky Way Satellite Galaxies and Outer-Halo Star Clusters with the Vera C. Rubin Observatory

The Open Journal of Astrophysics
We predict the sensitivity of the Vera C. Rubin Observatory Legacy Survey of Space and Time (LSST) to faint, resolved Milky Way satellite galaxies and outer-halo star clusters.
Kabelo Tsiane, Sidney Mau, Alex Drlica-Wagner, Jeffrey L. Carlin, Peter S. Ferguson, Keith Bechtol, Ethan O. Nadler, Annika H. G. Peter, Yao-Yuan Mao, Adam J. Thornton, LSST Dark Energy Science Collaboration   +10 more
doaj   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

A Galactic Self-portrait: Density Structure and Integrated Properties of the Milky Way Disk

The Astrophysical Journal
The evolutionary history of the Milky Way disk is imprinted in the ages, positions, and chemical compositions of individual stars. In this study, we derive the intrinsic density distribution of different stellar populations using the final data release ...
Julie Imig, Jon A. Holtzman, Gail Zasowski, Jianhui Lian, Nicholas F. Boardman, Alexander Stone-Martinez, J. Ted Mackereth, Moire K. M. Prescott, Rachael L. Beaton, Timothy C. Beers, Dmitry Bizyaev, Michael R. Blanton, Katia Cunha, José G. Fernández-Trincado, Catherine E. Fielder, Sten Hasselquist, Christian R. Hayes, Misha Haywood, Henrik Jönsson, Richard R. Lane, Steven R. Majewski, Szabolcs Mészáros, Ivan Minchev, David L. Nidever, Christian Nitschelm, Jennifer Sobeck   +25 more
doaj   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Galaxy Quenching at the High Redshift Frontier: A Fundamental Test of Cosmological Models in the Early Universe with JWST-CEERS

The Astrophysical Journal
We present an analysis of the quenching of star formation in massive galaxies ( M _* > 10 ^9.5 M _⊙ ) within the first 0.5–3 Gyr of the Universe’s history utilizing JWST-CEERS data.
Asa F. L. Bluck, Christopher J. Conselice, Katherine Ormerod, Joanna M. Piotrowska, Nathan Adams, Duncan Austin, Joseph Caruana, K. J. Duncan, Leonardo Ferreira, Paul Goubert, Thomas Harvey, James Trussler, Roberto Maiolino   +12 more
doaj   +1 more source