Results 81 to 90 of about 64,602 (241)

Clinical applications of next‐generation sequencing‐based ctDNA analyses in breast cancer: defining treatment targets and dynamic changes during disease progression

Molecular Oncology, EarlyView.
Circulating tumor DNA (ctDNA) offers a possibility for different applications in early and late stage breast cancer management. In early breast cancer tumor informed approaches are increasingly used for detecting molecular residual disease (MRD) and early recurrence. In advanced stage, ctDNA provides a possibility for monitoring disease progression and
Eva Valentina Klocker, Samantha Hasenleithner, Rupert Bartsch, Simon P. Gampenrieder, Daniel Egle, Christian F. Singer, Gabriel Rinnerthaler, Michael Hubalek, Katja Schmitz, Zsuzsanna Bago‐Horvath, Andreas Petzer, Sonja Heibl, Ellen Heitzer, Marija Balic, Michael Gnant   +14 more
wiley   +1 more source

Probing the dusty stellar populations of the Local Volume Galaxies with JWST/MIRI

, 2017
The Mid-Infrared Instrument (MIRI) for the {\em James Webb Space Telescope} (JWST) will revolutionize our understanding of infrared stellar populations in the Local Volume.
Glasse, Alistair, Jones, Olivia C., Justtanont, Kay, Meixner, Margaret   +3 more
core   +1 more source

Circulating tumor cells: advancing personalized therapy in small cell lung cancer patients

Molecular Oncology, EarlyView.
Small cell lung cancer (SCLC) is an aggressive form of lung cancer that spreads rapidly to secondary sites such as the brain and liver. Cancer cells circulating in the blood, “circulating tumor cells” (CTCs), have demonstrated prognostic value in SCLC, and evaluating biomarkers on CTCs could guide treatment decisions such as for PARP inhibitors ...
Prajwol Shrestha, Steven Kao, Veronica K. Cheung, Wendy A. Cooper, Nico van Zandwijk, John E. J. Rasko, Dannel Yeo   +6 more
wiley   +1 more source

A Robust Young Stellar Object Identification Method Based on Deep Learning

The Astrophysical Journal Supplement Series
Young stellar objects (YSOs) represent the earliest stage in the process of star formation, offering insights that contribute to the development of models elucidating star formation and evolution.
Lei Tan, Zhicun Liu, Xiaolong Wang, Ying Mei, Feng Wang, Hui Deng, Chao Liu   +6 more
doaj   +1 more source

Cell‐free and extracellular vesicle microRNAs with clinical utility for solid tumors

Molecular Oncology, EarlyView.
Cell‐free microRNAs (cfmiRs) are small‐RNA circulating molecules detectable in almost all body biofluids. Innovative technologies have improved the application of cfmiRs to oncology, with a focus on clinical needs for different solid tumors, but with emphasis on diagnosis, prognosis, cancer recurrence, as well as treatment monitoring.
Yoshinori Hayashi, Janelle‐Cheri Millen, Romela Irene Ramos, Jennifer A. Linehan, Timothy G. Wilson, Dave S. B. Hoon, Matias A. Bustos   +6 more
wiley   +1 more source

Flicker as a tool for characterizing planets through Asterodensity Profiling

, 2014
Variability in the time series brightness of a star on a timescale of 8 hours, known as 'flicker', has been previously demonstrated to serve as a proxy for the surface gravity of a star by Bastien et al. (2013).
Bastien, Fabienne A., Buchhave, Lars A., Chaplin, William J., Huber, Daniel, Kipping, David M., Stassun, Keivan G.   +5 more
core   +1 more source

Machine learning based stellar classification with highly sparse photometry data [version 2; peer review: 2 approved, 1 approved with reservations]

Open Research Europe
Background Identifying stars belonging to different classes is vital in order to build up statistical samples of different phases and pathways of stellar evolution.
Sebastian Scher, Seán Enis Cody, Albert Zijlstra, Iain McDonald, Nick Cox, Emma Alexander   +5 more
doaj  

KRAS and GNAS mutations in cell‐free DNA and in circulating epithelial cells in patients with intraductal papillary mucinous neoplasms—an observational pilot study

Molecular Oncology, EarlyView.
This study demonstrates that KRAS and GNAS mutations are more prevalent in patients with resected intraductal papillary mucinous neoplasms (IPMN) compared to those under clinical surveillance. GNAS mutations significantly differ between the two patient cohorts, indicating that their absence may serve as a potential biomarker to support conservative ...
Christine Nitschke, Marie Tölle, Philipp Walter, Kira Meißner, Mara Goetz, Jolanthe Kropidlowski, Andreas W. Berger, Jakob R. Izbicki, Felix Nickel, Thilo Hackert, Klaus Pantel, Harriet Wikman, Faik G. Uzunoglu   +12 more
wiley   +1 more source

On‐treatment dynamics of circulating extracellular vesicles in the first‐line setting of patients with advanced non‐small cell lung cancer: the LEXOVE prospective study

Molecular Oncology, EarlyView.
The LEXOVE prospective study evaluated plasma cell‐free extracellular vesicle (cfEV) dynamics using Bradford assay and dynamic light scattering in metastatic non‐small cell lung cancer patients undergoing first‐line treatments, correlating a ∆cfEV < 20% with improved median progression‐free survival in responders versus non‐responders.
Valerio Gristina, Viviana Bazan, Nadia Barraco, Simona Taverna, Mauro Manno, Samuele Raccosta, Anna Paola Carreca, Marco Bono, Tancredi Didier Bazan Russo, Francesco Pepe, Pasquale Pisapia, Lorena Incorvaia, Giuseppe Badalamenti, Giancarlo Troncone, Umberto Malapelle, Daniele Santini, Antonio Russo, Antonio Galvano   +17 more
wiley   +1 more source

MHD flows at astropauses and in astrotails

, 2014
The geometrical shapes and the physical properties of stellar wind -- interstellar medium interaction regions form an important stage for studying stellar winds and their embedded magnetic fields as well as cosmic ray modulation. Our goal is to provide a
Karlicky, Marian, Kraus, Michaela, Nickeler, Dieter H., Wiegelmann, Thomas   +3 more
core   +1 more source