Results 91 to 100 of about 2,699,264 (331)
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Astronomy & AstrophysicsAims. The two-dimensional spatial distribution of stellar specific angular momentum (sAM) within galaxies has never been analysed. We seek to identify the morpho-kinematics of this property and its correlation with the total stellar sAM (j★) and the ...
Pacheco-Arias Juan Manuel +3 more
doaj +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
SPLASH: A Rapid Host-based Supernova Classifier for Wide-field Time-domain Surveys
The Astrophysical Journal Supplement SeriesThe upcoming Legacy Survey of Space and Time conducted by the Vera C. Rubin Observatory will detect millions of supernovae (SNe) and generate millions of nightly alerts, far outpacing available spectroscopic resources.
Adam Boesky +4 more
doaj +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Seeking Spectroscopic Binaries with Data-driven Models
The Astrophysical JournalData-driven stellar classification has a long and important history in astronomy, dating as far back as Annie Jump Cannon’s “by-eye” classifications of stars into spectral types, still used today.
Isabel Angelo +2 more
doaj +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Classification of Astronomical Spectra Based on Multiscale Partial Convolution
The Astronomical JournalThe automated and efficient classification of astronomical spectra is an important research issue in the era of large sky surveys. Most current studies on automatic spectral classification primarily focus on specific data sets and demonstrate outstanding
Jingjing Wu +5 more
doaj +1 more source
The origin of sinusoidal brightness variations in F- to O-type stars through radial velocities
Astronomy & AstrophysicsContext. Stellar variability may originate from various phenomena such as binarity, pulsations, or rotation. These mechanisms can induce flux variations of similar magnitudes, shapes, and periods. Aims.
Šipková E. +5 more
doaj +1 more source