Results 121 to 130 of about 269 (256)

Optimization of Magnetic Milli‐Spinner for Robotic Endovascular Intervention

Advanced Robotics Research, EarlyView.
This work presents the design optimization of a multifunctional magnetic milli‐spinner for high‐speed propulsion and efficient clot debulking. The optimized design achieves an ultrafast swimming velocity of 55 cm/s (≈175 body lengths/s) in saline water, enabling stable upstream swimming against strong physiological flows and establishing magnetic milli‐
Lu Lu, Luca Higgins, Jack Bernardo, Ruike Renee Zhao   +3 more
wiley   +1 more source

Spectral Imager of the Solar Atmosphere: The First Extreme-Ultraviolet Solar Integral Field Spectrograph Using Slicers

Aerospace
Particle acceleration, and the thermalisation of energetic particles, are fundamental processes across the universe. Whilst the Sun is an excellent object to study this phenomenon, since it is the most energetic particle accelerator in the Solar System ...
Ariadna Calcines Rosario, Frederic Auchère, Alain Jody Corso, Giulio Del Zanna, Jaroslav Dudík, Samuel Gissot, Laura A. Hayes, Graham S. Kerr, Christian Kintziger, Sarah A. Matthews, Sophie Musset, David Orozco Suárez, Vanessa Polito, Hamish A. S. Reid, Daniel F. Ryan   +14 more
doaj   +1 more source

ELABELA Targets Mitochondria to Modulate Heart Development

Advanced Science, EarlyView.
The role of peptide ELABELA (ELA) in cardiomyocyte apoptosis and congenital heart disease (CHD) is unclear. ELA deficiency caused cardiomyocyte apoptosis and CHD. A novel ELA‐APJ‐AKT‐BCL2/BAX axis in regulating mitochondrial function and contributing to CHD pathogenesis was established.
Jian Wang, Qingjie Wang, Zhikang Xu, Shuang Zhou, Yue Zhou, Junjie Yang, Lingfeng Tong, Zhuo Meng, Mei Yang, Wen Zhao, Tie Yang, Hualin Wang, Jun Zhang, Rubin Tan, Lei Wang, Yuqiang Huang, Bin Zhou, Sun Chen, Bing Zhang, Jinxiang Yuan, Jianyuan Zhao, Alex F. Chen, Kun Sun   +22 more
wiley   +1 more source

Energy and Mass Transport Associated with Impulsive Spicular Flows in Solar Coronal Holes

The Astrophysical Journal Letters
How the solar atmosphere is heated from a temperature of about 5000 to 6000 K in the lower atmosphere to about 1–2 MK in the corona has challenged the astrophysical community for nearly 80 yr.
Lei Ni, Jun Lin, Tanmoy Samanta, Guanchong Cheng, Yifu Wang, Robert Erdélyi   +5 more
doaj   +1 more source

ZDHHC9‐Mediated Palmitoylation of ACSL4 Drives Ferroptosis in Diabetes Mellitus–Induced Erectile Dysfunction

Advanced Science, EarlyView.
ABSTRACT Diabetes mellitus‐induced erectile dysfunction (DMED) is a highly prevalent complication among diabetic patients; however, its underlying pathogenic mechanisms remain incompletely understood. Metabolic disorder is a hallmark of diabetes, yet its precise contribution to DMED progression is not well defined.
Wanyang Guo, Ming Xiao, Mengjun Huang, Dongzi Peng, Ruijiang Zeng, Ruilin Liu, Yuanqiao Zhao, Zhihan Ouyang, Yulong Hong, Zexian Ding, Zhuo Xing, Hao Su, Jinxiang Wang, Wenjun Mao, Xin Jin   +14 more
wiley   +1 more source

Time-lapse Very Long Baseline Interferometry Imaging of the Close Active Binary HR 1099

The Astrophysical Journal
We report multiepoch astrometric very long baseline interferometry observations of the chromospherically active binary HR 1099 (V711 Tau, HD 22468) at six epochs over 63 days using the Very Long Baseline Array at 22.2 GHz.
Walter W. Golay, Robert L. Mutel, Evan E. Abbuhl   +2 more
doaj   +1 more source

A Case for Electron-Astrophysics. [PDF]

Exp Astron (Dordr), 2022
Verscharen D, Wicks RT, Alexandrova O, Bruno R, Burgess D, Chen CHK, D'Amicis R, De Keyser J, de Wit TD, Franci L, He J, Henri P, Kasahara S, Khotyaintsev Y, Klein KG, Lavraud B, Maruca BA, Maksimovic M, Plaschke F, Poedts S, Reynolds CS, Roberts O, Sahraoui F, Saito S, Salem CS, Saur J, Servidio S, Stawarz JE, Štverák Š, Told D.   +29 more
europepmc   +1 more source

Organ‐Specific and Conserved Regulatory Logic Orchestrates Gene Expression in the Embryonic Mesothelium

Advanced Science, EarlyView.
Integrated multi‐omic profiling maps the gene‐regulatory landscape of the coelomic mesothelium across heart, lung, and pancreas. A cardiac‐restricted regulatory program is uncovered in which TBX20 activates heart mesothelial (epicardial) cis‐regulatory elements, while MAF emerges as a conserved regulator of mesothelial identity.
Quang Minh Dang, Nicola Smart, Andia Nicole Redpath, Joaquim Miguel Vieira   +3 more
wiley   +1 more source

Macrophage Extracellular Traps in Immunity and Cancer

Advanced Science, EarlyView.
As a macrophage‐mediated innate defense mechanism, the dysregulated release of METs drives chronic inflammation and influences tumor progression. Furthermore, METs exhibit a functional duality within the tumor microenvironment, capable of both promoting and suppressing tumor development.
Junyao Li, Eugenie Nepovimova, Adam Grundel, Lukas Peter, Qinghua Wu, Kamil Kuca   +5 more
wiley   +1 more source

Selective Inhibition of Integrin β3 Topology Provides a Safer Antithrombotic Strategy

Advanced Science, EarlyView.
Current integrin αIIbβ3 inhibitors effectively reduce thrombosis but also increase bleeding risk. During thrombosis, high shear blood flow can directly activate the integrin αIIbβ3 via a distinct topological change in the β3 transmembrane domain, independent of hemostatic platelet signaling.
Joonha Lee, Chul‐Gyun Lim, Pothiappan Vairaprakash, Jong‐Min Kim, Jiyoon Kim, Ji‐Young Park, Klaus M. Hahn, Hyunbo Shim, Hae Woong Choi, Tobias S. Ulmer, Soon Jun Hong, Chungho Kim   +11 more
wiley   +1 more source