Results 151 to 160 of about 3,529,940 (309)

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard   +5 more
wiley   +1 more source

zoomies: A Tool to Infer Stellar Age from Vertical Action in Gaia Data

open access: yesThe Astrophysical Journal
Stellar age measurements are fundamental to understanding a wide range of astronomical processes, including Galactic dynamics, stellar evolution, and planetary system formation. However, extracting age information from main-sequence stars is complicated,
Sheila Sagear   +5 more
doaj   +1 more source

The Nuclear Dynamics of M32. I. Data and Stellar Kinematics [PDF]

open access: bronze, 2001
C. L. Joseph   +16 more
openalex   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

open access: yesMolecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son   +13 more
wiley   +1 more source

Zones of Tayler Instability in Stars

open access: yesThe Astrophysical Journal
The Tayler instability (TI) of toroidal magnetic fields is a candidate mechanism for driving turbulence, angular momentum (AM) transport, and dynamo action in stellar radiative zones. Recently V. A. Skoutnev & A. M.
Valentin A. Skoutnev   +1 more
doaj   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

open access: yesMolecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto   +8 more
wiley   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

open access: yesMolecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié   +13 more
wiley   +1 more source

Spectral stellar dynamics

open access: yesThe Astrophysical Journal, 1982
Binney, J, Spergel, D
openaire   +2 more sources

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