Results 131 to 140 of about 3,320,308 (251)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

A Stellar Conversation with scientist, engineer and astronaut Jan Davis

, 2008
Includes descriptive metadata provided by producer in MP3 file: "Stellar Conversations - Podcasts - A Stellar Conversation with scientist, engineer and astronaut Jan Davis." By news@vanderbilt.edu (Vanderbilt News Service).
Chappell, Rick, 1943-, Davis, Jan, 1953-
core  

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

The Shape of Stellar Convection

Recent space missions such as Kepler, TESS, and soon PLATO have provided an abundance of high-quality stellar data, highlighting the need for more accurate models of stellar structure and evolution.
Mary Geer Dethero
core   +1 more source

Identifying the principal mechanism of star formation feedback. [PDF]

Sci Adv
Li C, Li R, Qiu K, Krco M, Li D, Wang H, Lyu X, Duan Y, Fang M, Chen X, Wang L, Feng H, Zhang S, Zhang M, Zhang S, Cao Y, Wang Y, Gong Y, Du F, Chen Z, Su Y, Ma Y, Xing Y, Zheng Y, Zhang T, Niu S, Li C, Liu J, Zhang Z, Guo Y.   +29 more
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Absolute wavelength shifts - A new diagnostic for rapidly rotating stars

, 2004
Accuracies reached in space astrometry now permit. the accurate determination of astrometric radial velocities. without any use of spectroscopy. Knowing this true stellar motion, spectral shifts; intrinsic to stellar atmospheres can be identified, for ...
Dravins, Dainis,
core  

Machine learning-enabled membership determination of open cluster AH03_J0748-26.9 using Gaia DR3 astrometry. [PDF]

Sci Rep
Badawy WA, Abdel Rahman HI.
europepmc   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

An Agent-Based Model of the Stellar Mass Distribution. [PDF]

Entropy (Basel)
Olguín-Rodríguez ER, Gershenson C, Vázquez-Semadeni E.   +2 more
europepmc   +1 more source