Results 111 to 120 of about 114,576 (290)
The Dynamics of a Stellar System [PDF]
Monthly Notices of the Royal Astronomical Society, 1937 G. L. Clark, W. M. Smart
openaire +2 more sources
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Semianalytical Fokker–Planck Models for Nuclear Star Clusters
The Astrophysical JournalWe study the dynamics of nuclear star clusters, the dense stellar environments surrounding massive black holes in the centers of galaxies. We consider angular momentum diffusion due to two-body scatterings among stellar objects and energy advection due ...
Karamveer Kaur, Barak Rom, Re’em Sari
doaj +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Iron Snails: Nonequilibrium Dynamics and Spiral Abundance Patterns
The Astrophysical JournalGalaxies are not in a dynamical steady state: they continually undergo perturbations, e.g., from infalling dwarf galaxies and dark matter substructure. After a dynamical perturbation, stars phase mix toward a new steady state; in so doing, they generally
Neige Frankel +4 more
doaj +1 more source
Relativistic Stellar Dynamics [PDF]
Symposium - International Astronomical Union, 1983 Three main areas of relativistic stellar dynamics are reviewed: (a) Relativistic clusters, (b) Systems containing a massive black hole, and (c) Perturbed expanding Universes. The emphasis is on the use of orbit perturbations.
openaire +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Stellar Distributions around Supermassive Black Holes in Gas-rich Nuclear Star Clusters
The Astrophysical Journal LettersWe study the stellar distribution around supermassive black holes in gas-rich nuclear star clusters (NSCs). NSCs could contain vast amounts of gas, which contribute significantly to shaping the stellar distribution, typically altering the stellar density
Mor Rozner, Enrico Ramirez-Ruiz
doaj +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source