Results 91 to 100 of about 3,320,308 (251)

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Gravitational lensing & stellar dynamics

, 2006
Strong gravitational lensing and stellar dynamics provide two complementary and orthogonal constraints on the density profiles of galaxies. Based on spherically symmetric, scale-free, mass models, it is shown that the combination of both techniques is ...
Combes, F, Deffayet, C, Fort, B, Koopmans, L. V. E., Mamon, GA, L.V.E. Koopmans   +5 more
core   +1 more source

Semianalytical Fokker–Planck Models for Nuclear Star Clusters

The Astrophysical Journal
We study the dynamics of nuclear star clusters, the dense stellar environments surrounding massive black holes in the centers of galaxies. We consider angular momentum diffusion due to two-body scatterings among stellar objects and energy advection due ...
Karamveer Kaur, Barak Rom, Re’em Sari
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Stellar Distributions around Supermassive Black Holes in Gas-rich Nuclear Star Clusters

The Astrophysical Journal Letters
We study the stellar distribution around supermassive black holes in gas-rich nuclear star clusters (NSCs). NSCs could contain vast amounts of gas, which contribute significantly to shaping the stellar distribution, typically altering the stellar density
Mor Rozner, Enrico Ramirez-Ruiz
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Perspectives on the physics of late-type stars from beyond low earth orbit, the moon and mars

npj Microgravity
With the new discoveries enabled thanks to the recent space missions, stellar physics is going through a revolution. However, these discoveries opened the door to many new questions that require more observations.
Savita Mathur, Ângela R. G. Santos
doaj   +1 more source

Spin–spin coupling in stellar binaries

Astronomy & Astrophysics
Spin–orbit misalignment is increasingly observed in binary stars, but its origin remains uncertain. We study the secular spin dynamics of stellar binaries and derive the associated Cassini states. We isolate a spin–spin resonance that arises when the two
Correia Alexandre C. M.
doaj   +1 more source